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Table 3 Effect of pantoprazole and lycopene on biochemical markers of oxidative stress in experimental animals

From: Effect of lycopene against gastroesophageal reflux disease in experimental animals

Group Treatment Glutathione (mg %) Superoxide dismutase (unit of SOD/ mg of protein) Catalase (nM of H 2 O 2 /min /mg of protein) Thiobarbituric acid reactive substances (nM of MDA/mg of protein) Protein carbonyl (nM/ml)
Group-I Sham control (Normal saline,3 ml/kg, p.o) 4.71 ± 0.42*** 110.39 ± 66.13 4.45 ± 0.40*** 1.20 ± 0.06*** 48.18 ± 1.82***
Group-II Esophagitis control (Normal saline,3 ml/kg, p.o) 3.69 ± 0.10 64.21 ± 31.76 2.58 ± 0.71 5.17 ± 0.01 162.12 ± 1.74
Group-III Lycopene (50 mg/kg, p.o) 4.78 ± 0.10*** 71.70 ± 17.90 4.05 ± 0.78** 3.28 ± 0.07*** 129.39 ± 5.04***
Group-IV Lycopene (100 mg/kg,p.o) 4.02 ± 0.20c 64.68 ± 15.09 4.10 ± 0.37*** 3.03 ± 0.03***c 112.50 ± 3.00***c
Group-V Pantoprazole (30 mg/kg, p.o) 4.26 ± 0.05** 67.89 ± 27.06 3.44 ± 0.38 2.84 ± 0.04*** 98.26 ± 3.07***
  1. Each group contains six animals. Values are represented as mean ± SD.
  2. Statistical significance compared to toxic control using one-way ANOVA followed by Bonferroni test (**P < 0.01, and ***P < 0.001).
  3. Statistical significance compared between lycopene (50 mg/kg) and lycopene (100 mg/kg) using one-way ANOVA followed by Bonferroni test (c P < 0.001).