Skip to main content

Table 2 Effect of pantoprazole and lycopene on pH, volume of gastric juices total acidity, free acidity and esophagitis index in experimental animals

From: Effect of lycopene against gastroesophageal reflux disease in experimental animals

Group Treatment Intestinal pH Volume of gastric juices (ml/100 g) Total acidity (mEq/l) Free acidity (mEq/l) Esophagitis index
Group-I Sham control (Normal saline, 3 ml/kg,p.o) 3.55 ± 0.31*** 2.58 ± 0.38 (14.00) 29.39 ± 0.97*** (18.95) 20.99 ± 1.31*** (36.43) 0.38 ± 0.35*** (87.46)
Group-II Esophagitis control (Normal saline, 3 ml/kg,p.o) 2.73 ± 0.28 3.00 ± 0.45 36.26 ± 0.65 33.02 ± 0.98 3.03 ± 0.34
Group-III Lycopene (50 mg/kg,p.o) 3.65 ± 0.23*** 1.57 ± 0.12 (47.66) 30.056 ± 0.93*** (17.10) 26.32 ± 1.14*** (20.29) 1.33 ± 0.12*** (56.10)
Group-IV Lycopene (100 mg/kg,p.o) 4.00 ± 0.34*** 1.87 ± 0.12 (37.66) 28.26 ± 0.79***a (20.06) 25.79 ± 1.09*** (21.89) 1.17 ± 0.16*** (61.38)
Group-V Pantoprazole (30 mg/kg,p.o) 3.92 ± 0.30*** 1.35 ± 3.40 (55.00) 26.99 ± 1.36*** (25.56) 22.32 ± 1.14*** (32.40) 0.77 ± 0.16*** (74.59)
  1. Each group contains six animals. Values are represented as mean ± SD. Statistical significance compared to toxic control using one-way ANOVA followed by Bonferroni test (***P < 0.001). Values in parenthesis represent percentage inhibition.
  2. Statistical significance compared between lycopene (50 mg/kg) and lycopene (100 mg/kg) using one-way ANOVA followed by Bonferroni test (a P < 0.05).
\