Figure 6From: Medicinal value of asiaticoside for Alzheimer’s disease as assessed using single-molecule-detection fluorescence correlation spectroscopy, laser-scanning microscopy, transmission electron microscopy, and in silico dockingRepresentative transmission electron microscopic (TEM) views of the effects of asiaticoside on fibrillation. A: Control (Aβ1–42 alone), Insets of A show complete fibers, protofibrills, and oligomeric globular amyloid species appeared to arrange in lines (red arrow) to form long fibers; B: Aβ1–42 + 10 μM asiaticoside; and C: Aβ1–42 + 20 μM asiaticoside. The fibers (B, C) became unstructured, diffused, and irregular, sometimes they appeared as globular structures (insets of B and C). The globular structures appeared more dispersed at 20 μM of concentrations of asiaticoside than those at 10 μM. These results indicate that asiaticoside clearly inhibited Aβ1–42 fibrillation.Back to article page