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Figure 6 | BMC Complementary and Alternative Medicine

Figure 6

From: Medicinal value of asiaticoside for Alzheimer’s disease as assessed using single-molecule-detection fluorescence correlation spectroscopy, laser-scanning microscopy, transmission electron microscopy, and in silico docking

Figure 6

Representative transmission electron microscopic (TEM) views of the effects of asiaticoside on fibrillation. A: Control (Aβ1–42 alone), Insets of A show complete fibers, protofibrills, and oligomeric globular amyloid species appeared to arrange in lines (red arrow) to form long fibers; B: Aβ1–42 + 10 μM asiaticoside; and C: Aβ1–42 + 20 μM asiaticoside. The fibers (B, C) became unstructured, diffused, and irregular, sometimes they appeared as globular structures (insets of B and C). The globular structures appeared more dispersed at 20 μM of concentrations of asiaticoside than those at 10 μM. These results indicate that asiaticoside clearly inhibited Aβ1–42 fibrillation.

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