Figure 4From: Qian Yang Yu Yin Granule-containing serum inhibits angiotensin II-induced proliferation, reactive oxygen species production, and inflammation in human mesangial cells via an NADPH oxidase 4-dependent pathwayQYGS counteracts Ang II-induced up-regulation of NOX4, p22phox, and GTP-Rac1 in HMCs. Cells were pre-incubated with 5% VS or with 1.25%, 2.5%, or 5% QYGS for 1 h prior to treatment with 10−4 mmol/L of Ang II. RT-PCR and Western blot were carried out to detect mRNA (A) and protein levels (B). Data are expressed as means ± SEM (n = 3). **P < 0.01 as ompared with the vehicle group. #P < 0.05, ##P < 0.01 as compared with the Ang II model group.Back to article page