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Table 2 Association of FTO rs7193144 (T > C) with determination of constitutional type

From: The obesity-risk variant of FTO is inversely related with the So-Eum constitutional type: genome-wide association and replication analyses

Population

SE versus NSE

TE versus NTE

SY versus NSY

MAF (n)

  

MAF (n)

  

MAF (n)

  

SE

NSE

OR (95% CI)

P

TE

NTE

OR (95% CI)

P

SY

NSY

OR (95% CI)

P

Stage 1

0.106 (1903)

0.140 (1903)

0.714 (0.620, 0.823)

3.07E-06

0.135 (1903)

0.114 (1903)

1.224 (1.067, 1.405)

0.00395

0.122 (1902)

0.131 (1903)

0.918 (0.801, 1.053)

0.222

Stage 2

0.122 (833)

0.146 (835)

0.764 (0.616, 0.945)

0.0135

0.146 (837)

0.119 (831)

1.422 (1.144, 1.772)

0.00161

0.119 (831)

0.137 (835)

0.820 (0.664, 1.013)

0.0667

Combined

0.111 (2736)

0.142 (2738)

0.729 (0.648, 0.820)

1.47E-07

0.138 (2740)

0.116 (2734)

1.287 (1.120, 1.478)

3.87E-05

0.121 (2733)

0.133 (2738)

0.888 (0.792, 0.996)

0.0585

Heterogeneity

Q = 0.293, p = 0.588, I2 = 0

Q = 1.194, p = 0.275, I2 = 16.22

Q = 0.834, p = 0.361, I2 = 0

  1. Abbreviations: FTO fat mass and obesity–associated, SE So-Eum, NSE non-So-Eum, TE Tae-Eum, NTE non-Tae-Eum, SY So-Yang, NSY non-So-Yang, MAF minor allele frequency, OR odds ratio, 95% CI, 95% confidence interval.
  2. Logistic regression analysis with adjustment for age and sex in an additive genetic model: (stage 1) genome-wide association analysis in the KoGES population; (stage 2) replication analysis in the KCMS population.