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Table 1 Details of the product, active ingredients, daily dose and cost per dose

From: A survey of the availability in Canadian pharmacy chains of over-the-counter natural health products for menopause symptoms

a. Products with multiple active ingredients
Product name/Manufacturer Health Canada Licence Number Ingredients active for menopause symptoms, amount per tablet 5 most common active ingredients in bold Recommended daily dose (# of tablets, frequency) Range of cost of average daily recommended dosea(CAD$)
Swiss Natural HRT® Regular/Valeant Canada LP/S.E.C. 80038543 Black cohosh (30 mg), chaste tree (100 mg), soy isoflavones (70 mg), wild yam (50 mg), burdock (50 mg) 1, twice daily $0.36-$0.93
Swiss Natural HRT® Extra Strength/Valeant Canada LP/S.E.C. 80019270 Black cohosh (100 mg), chaste tree (200 mg), soy isoflavones (100 mg), wild yam (50 mg), burdock (100 mg) 1, daily $0.18-$0.47
Swiss Natural HRT® Nightime/Valeant Canada LP/S.E.C. 80002152 Black cohosh (100 mg), lemon balm (300 mg), passion flower (150 mg) 1, at night $0.36-$0.47
Estroven®/i-Health, Inc. 80024706 Black cohosh (40 mg), soy isoflavones (37.5 mg), calcium (150 mg), folic acid (400 μg), kudzu (100 mg), magnolia (15 mg), vitamin E (30 IU), thiamin (2 mg), riboflavin (2 mg), niacinamide (20 mg), vitamin B6 (10 mg), vitamin B12 (6 μg), selenium (70 μg), boron glycinate (1.5 mg), Chinese-date seed (120 mg) 1, daily $0.61-$0.86
Estroven® Maximum Strength/i-Health, Inc. 80032569 Black cohosh (80 mg), calcium (138 mg), chaste tree (75 mg), folic acid (400 μg), green tea (60 mg), soy isoflavones (102.5 mg), vitamin D3 (25 μg), vitamin E (30 IU), thiamin (5 mg), riboflavin (5 mg), niacinamide (20 mg), vitamin B6 (20 mg), vitamin B12 (25 μg), selenium (70 μg), boron glycinate (1.5 mg), chromium (120 μg), L-theanine (50 mg), caffeine (49 mg), cranberry (25 mg) 1, daily $1.00-$1.17
Life Brand™ Menopause Relief/GFR Pharma Ltd. Not available Black cohosh (20 mg), red clover isoflavones (42 mg), soy isoflavones (425 mg) 1, daily $0.33
femMED® Menopause Relief/femMED Formulas Inc. 80025767 Black cohosh (40 mg), dong quai (125 mg), pomegranate (75 mg), damiana (75 mg), partridge berry (75 mg), motherwort (50 mg), schizandra (50 mg) 1, twice daily $0.70-$1.10
webber naturals® FemmeCalm Menopause Formula/WN Pharmaceuticals Ltd. 80046012 Black cohosh (80 mg), chaste tree (80 mg), dong quai (100 mg), gamma-oryzanol (75 mg), hesperidin (30 mg) 1, three times daily $0.66
MENOsmart™ Plus/Lorna Vanderhaeghe Health Solutions, Inc. 80025898 Black cohosh (80 mg), chaste tree (80 mg), dong quai (100 mg), gamma-oryzanol (75 mg), hesperidin (75 mg), sage (75 mg) 2, morning and night $1.10
b. Products with single active ingredient
Product name/Manufacturer Health Canada Licence Number Ingredients active for menopause symptoms, amount per tablet Recommended daily dose (# of tablets, frequency) Range of cost of average daily recommended dose a (CAD$)
up&up™ Black Cohosh/WN Pharmaceuticals Ltd. 80007421b Black cohosh (40 mg) 1-2, daily $0.24
London Naturals® Black Cohosh/WN Pharmaceuticals Ltd. 80007421b Black cohosh (40 mg) 1-2, daily $0.27
equate® Black Cohosh/Vita Health Products Inc. 02238871 Black cohosh (40 mg) 1, daily $0.12
Holista® Black Cohosh/Holista Health (Canada) Inc. 80010287 Black cohosh (40 mg) 1-2, daily $0.07-$0.09
Be.better™ Black Cohosh/WN Pharmaceuticals Ltd. 80007421b Black cohosh (40 mg) 1-2, daily $0.29
Promensil® Regular Strength/PharmaCare Laboratories 80015467 Red clover isoflavones (40 mg) 1, daily $0.67-$1.10
Promensil® Double Strength/PharmaCare Laboratories 80016071 Red clover isoflavones (80 mg) 1, daily $1.23-$1.33
webber naturals® Soy Isoflavone Complex/WN Pharmaceuticals Ltd. 80015647 Soy isoflavones (50 mg) 7, daily $0.77
Menoconfort Forté c/IRB Yves Ponroy Canada Inc. 80021605 Soy isoflavones (300 mg)c 1, at night $0.55
i-Cool®/i-Health, Inc. 80033608 Synthetic soy isoflavones, genistein (30 mg) 1, daily $0.83-$0.87
A. Vogel™ Menopause/Bioforce Canada Inc. 80034857 Sage (3400 mg) 1, 1 to 5 times daily $2.33-$2.50
  1. Notes: aproducts without a range of daily cost were either only found in a single pharmacy or found in several pharmacies at a single price.
  2. bproducts share the same licence number.
  3. cMenoconfort Forté packages include a daytime NHP for “radiant skin”.
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