Renal histopathology was observed after 10 weeks treatment in mice under light microscopy. (A-C) HE stained glomeruli, ×400 magnification. (D-F) PAS stained renal slices, ×400 magnification. (G-I) Masson’s Trichrome stained renal sections, ×400 magnification. (A, D, G) KK-Ay vehicle mice. (B, E, H), KK-Ay mice treated with Qiwei granules. (C, F, I) C57BL/6J normal mice. (J) Glomerular mesangial matrix expansion and (K) fibrosis of three groups were determined semi-quantitatively by PAS and Masson’s Trichrome staining. Data were presented as means ± SEM. *P < 0.05; **P < 0.01 compared to KK-Ay vehicle group.