Table 1 Effect of oral administration of TS extract fractions, rofecoxib, and diclofenac on abdominal writhing in mice induced by intraperitoneal injection of acetic acid

Control by Vehicle (10 ml/kg)

127.8 ± 13.46

TSL1 (1 g/kg)

76.9 ± 20.9

39.9%

< 0.001

TSL2 (1 g/kg)

102.9 ± 28.3

19.5%

< 0.05

TSL3 (1 g/kg)

112.8 ± 14.8

11.7%

0.052

TSL4 (1 g/kg)

117.4 ± 16.4

8.1%

0.188

TSL5 (1 g/kg)

113.3 ± 14.6

11.4%

0.057

TSL1 (0.3 g/kg)

79.3 ± 21.7

38.0%

< 0.001

TSL1 (0.1 g/kg)

67.8 ± 20.7

46.9%

< 0.001

TSL1 (0.03 g/kg)

85.0 ± 24.9

31.1%

< 0.001

TSL1 (0.01 g/kg)

113.1 ± 17.2

11.7%

0.092

Rofecoxib (1.5 mg/kg)

93.4 ± 13.2

26.9%

< 0.01

Rofecoxib (5 mg/kg)

84.6 ± 11.0

33.8%

< 0.001

Diclofenac (5 mg/kg)

84.9 ± 13.1

33.5%

< 0.001

Diclofenac (10 mg/kg)

72.0 ± 14.5

43.7%

< 0.001