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Table 1 Effect of oral administration of TS extract fractions, rofecoxib, and diclofenac on abdominal writhing in mice induced by intraperitoneal injection of acetic acid

From: Toona sinensis leaf extract has antinociceptive effect comparable with non-steroidal anti-inflammatory agents in mouse writhing test

Dose Writhing response* Percentage of inhibition Pvalue
(No. of writhes in 30 min)
Control by Vehicle (10 ml/kg) 127.8 ± 13.46   
TSL1 (1 g/kg) 76.9 ± 20.9 39.9% < 0.001
TSL2 (1 g/kg) 102.9 ± 28.3 19.5% < 0.05
TSL3 (1 g/kg) 112.8 ± 14.8 11.7% 0.052
TSL4 (1 g/kg) 117.4 ± 16.4 8.1% 0.188
TSL5 (1 g/kg) 113.3 ± 14.6 11.4% 0.057
TSL1 (0.3 g/kg) 79.3 ± 21.7 38.0% < 0.001
TSL1 (0.1 g/kg) 67.8 ± 20.7 46.9% < 0.001
TSL1 (0.03 g/kg) 85.0 ± 24.9 31.1% < 0.001
TSL1 (0.01 g/kg) 113.1 ± 17.2 11.7% 0.092
Rofecoxib (1.5 mg/kg) 93.4 ± 13.2 26.9% < 0.01
Rofecoxib (5 mg/kg) 84.6 ± 11.0 33.8% < 0.001
Diclofenac (5 mg/kg) 84.9 ± 13.1 33.5% < 0.001
Diclofenac (10 mg/kg) 72.0 ± 14.5 43.7% < 0.001
  1. *Values are expressed as mean ± S.D. (n = 8).