Table 1 Antidiarrhoeal effect of the crude extract of Matricaria chamomilla (Mc.Cr) against castor oil (10 mL/kg)-induced diarrhoea in mice without and with pre-administration of 3 mg/kg glibenclamide (GB) or 5 mg/kg 4-aminopyridine (4-AP)
Group no. | Treatment | Dose (mg/kg) | Mean defecation/group | Mean no. of wet feces/group | Mean no. of dry feces/group | % Protection |
|---|---|---|---|---|---|---|
1 | Castor oil (10 mL/kg) + Saline | 10 | 8.92 ± 1.24 | 7.81 ± 2.11 | 1.11 ± 0.21 | 12.4% |
2 | Castor oil + Cromakalim | 10 | 6.67 ± 0.90# | 2.32 ± 0.40### | 4.35 ± 1.70# | 65.2% |
3 | Castor oil + Loperamide | 10 | 4.70 ± 0.90### | 1.07 ± 0.30### | 3.63 ± 0.90# | 77.2% |
4 | Castor oil + Mc.Cr (p.o) | 150 | 5.47 ± 1.37** | 3.20 ± 0.50** | 2.27 ± 0.58* | 41.4% |
5 | Castor oil + Mc.Cr (p.o.) | 300 | 4.20 ± 0.29*** | 1.61 ± 0.92*** | 2.59 ± 0.33* | 61.7% |
Effect of different treatments in the presence of GB or 4-AP | ||||||
6 | Castor oil + GB + Cromakalim | 3 + 10 | 7.40 ± 0.95$ | 5.50 ± 0.70$$$ | 1.90 ± 0.85$$ | 25.6% |
7 | Castor oil + 4-AP + Cromakalim | 5 + 10 | 6.70 ± 0.50 | 2.80 ± 0.75 | 3.90 ± 0.35$ | 58.2% |
8 | Castor oil + GB + Loperamide | 3 + 10 | 4.90 ± 0.39 | 1.40 ± 0.50 | 3.50 ± 0.90 | 71.4% |
9 | Castor oil + 4-AP + Loperamide | 5 + 10 | 5 ± 1.73 | 1.31 ± 0.90 | 3.69 ± 0.45 | 73.8% |
10 | Castor oil + GB + Mc.Cr | 3 + 150 | 5.83 ± 0.50 | 3.84 ± 0.37$ | 1.99 ± 0.36 | 34.1% |
11 | Castor oil + 4-AP + Mc.Cr | 5 + 150 | 6.11 ± 0.49$ | 4.73 ± 0.31$$ | 1.38 ± 0.41$ | 22.5% |
12 | Castor oil + GB + Mc.Cr | 3 + 300 | 5.56 ± 0.50$ | 3.06 ± 0.57$$ | 2.50 ± 0.62 | 44.9% |
13 | Castor oil + 4-AP + Mc.Cr | 5 + 300 | 5.80 ± 0.46$$ | 4.07 ± 0.57$$$ | 1.73 ± 0.70$ | 29.8% |