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Table 1 Antidiarrhoeal effect of the crude extract of Matricaria chamomilla (Mc.Cr) against castor oil (10 mL/kg)-induced diarrhoea in mice without and with pre-administration of 3 mg/kg glibenclamide (GB) or 5 mg/kg 4-aminopyridine (4-AP)

From: Antidiarrhoeal, antisecretory and antispasmodic activities of Matricaria chamomilla are mediated predominantly through K+-channels activation

Group no. Treatment Dose (mg/kg) Mean defecation/group Mean no. of wet feces/group Mean no. of dry feces/group % Protection
1 Castor oil (10 mL/kg) + Saline 10 8.92 ± 1.24 7.81 ± 2.11 1.11 ± 0.21 12.4%
2 Castor oil + Cromakalim 10 6.67 ± 0.90# 2.32 ± 0.40### 4.35 ± 1.70# 65.2%
3 Castor oil + Loperamide 10 4.70 ± 0.90### 1.07 ± 0.30### 3.63 ± 0.90# 77.2%
4 Castor oil + Mc.Cr (p.o) 150 5.47 ± 1.37** 3.20 ± 0.50** 2.27 ± 0.58* 41.4%
5 Castor oil + Mc.Cr (p.o.) 300 4.20 ± 0.29*** 1.61 ± 0.92*** 2.59 ± 0.33* 61.7%
Effect of different treatments in the presence of GB or 4-AP
6 Castor oil + GB + Cromakalim 3 + 10 7.40 ± 0.95$ 5.50 ± 0.70$$$ 1.90 ± 0.85$$ 25.6%
7 Castor oil + 4-AP + Cromakalim 5 + 10 6.70 ± 0.50 2.80 ± 0.75 3.90 ± 0.35$ 58.2%
8 Castor oil + GB + Loperamide 3 + 10 4.90 ± 0.39 1.40 ± 0.50 3.50 ± 0.90 71.4%
9 Castor oil + 4-AP + Loperamide 5 + 10 5 ± 1.73 1.31 ± 0.90 3.69 ± 0.45 73.8%
10 Castor oil + GB + Mc.Cr 3 + 150 5.83 ± 0.50 3.84 ± 0.37$ 1.99 ± 0.36 34.1%
11 Castor oil + 4-AP + Mc.Cr 5 + 150 6.11 ± 0.49$ 4.73 ± 0.31$$ 1.38 ± 0.41$ 22.5%
12 Castor oil + GB + Mc.Cr 3 + 300 5.56 ± 0.50$ 3.06 ± 0.57$$ 2.50 ± 0.62 44.9%
13 Castor oil + 4-AP + Mc.Cr 5 + 300 5.80 ± 0.46$$ 4.07 ± 0.57$$$ 1.73 ± 0.70$ 29.8%
  1. p.o. (per oral), Values shown are mean ± S.E.M. of 6 determinations.
  2. #p <0.05 and ###p <0.001 show a comparison of group #2 and 3 with group #1.
  3. *p <0.05, **p <0.01 and ***p <0.001show a comparison of group # 4 and 5 with group #1.
  4. $p <0.05, $$p <0.01 and $$$p <0.001 show a comparison of group # 6–13 with their respective treatments without GB or 4-AP (One-way ANOVA followed by Dunnet’s test).