Antidiarrhoeal and antisecretory effects ofMatricaria chamomillain mice. The dose-dependent inhibitory effect of the crude extract of Matricaria chamomilla (Mc. Cr) on castor oil-induced fluid accumulation in the small intestine of mice, (A) without and (B) with glibenclamide (GB) or 4-aminopyridine (4-AP). Intestinal fluid accumulation is expressed as Pi/Pm × 1000, whereas Pi is the weight of the small intestine and Pm is the weight (in g) of the mouse. The values are mean ± s.e.m., n = 6. *p < 0.05, **p < 0.01 and ***p < 0.001 (Unpaired t-test or One-way ANOVA followed by Dunnett’s test).