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Table 2 Synergistic effects of ACV and IPAD on HSV infection

From: Synergistic effects of acyclovir and 3, 19- isopropylideneandrographolide on herpes simplex virus wild types and drug-resistant strains

Compounds combination ratio Compound concentration (μM) % Inhibition of IPAD + ACV Experimental CI Description
IPAD ACV
HSV-2
  20.50 - 100   
  - 20.20 100   
IC 100 xIC 100 20.50 20.20 100   
IC 50 xIC 50 18.01 0.80 100   
IC 10 xIC 10 15.00 0.04 100 <1 synergism
  18.01 0.0008 50   
  0.004 0.80 50   
HSV-1 KOS
  20.50 - 100   
  - 20.20 100   
IC 100 xIC 100 20.50 20.20 100   
IC 50 xIC 50 16.96 0.49 100   
IC 10 xIC 10 13.87 0.02 100 <1 synergism
  16.96 0.008 50   
  0.009 0.49 50   
HSV-1 ACGr4
  20.50 - 100   
  - 2,220.00 100   
IC 100 xIC 100 20.50 2,220.00 100   
IC 50 xIC 50 17.89 575.91 100   
IC 10 xIC 10 14.96 25.36 88.5 <1 synergism
  17.89 58.16 50   
  0.89 575.91 50   
HSV-1 dlsptk
  20.50 - 100   
  - 2,220.00 100   
IC 100 xIC 100 20.50 2,220.00 100   
IC 50 xIC 50 16.86 450.25 98.55   
IC 10 xIC 10 15.00 23.12 88.41 < 1 synergism
  16.86 4.51 50   
  0.85 450.25 50   
HSV-1 dxpIII
  20.50 - 100   
  - 2,220.00 100   
IC 100 xIC 100 20.50 2,220.00 100   
IC 50 xIC 50 17.12 161.45 100   
IC 10 xIC 10 14.90 18.70 100 < 1 synergism
  17.12 0.16 50   
  0.009 161.45 50