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Table 1 Cytotoxic effect, anti-viral activity and selective index of IPAD and ACV at the post-entry step

From: Synergistic effects of acyclovir and 3, 19- isopropylideneandrographolide on herpes simplex virus wild types and drug-resistant strains

  CC50a(μM) Anti-viral activitybagainst
HSV-2 HSV-1 KOS HSV-1 ACGr4 HSV-1 dlsptk HSV-1 dxpIII
IC50(μM) SIc IC50(μM) SIc IC50(μM) SIc IC50(μM) SIc IC50(μM) SIc
IPAD 39.71 18.01 2.20 16.96 2.34 17.89 2.22 16.86 2.36 17.12 2.32
ACV >6,400 0.80 >8,000 0.49 >13,061 575.91 >11.11 450.25 >14.21 161.45 >39.64
  1. The value represents mean of three independent experiments.
  2. aCytotoxic effect was determined using the MTT assay. CC50 was the concentration reducing cell viability by 50% relative to controls.
  3. bAnti-viral activity was determined using the CPE reduction assay. IC50 was the concentration that reduced HSV-induced CPE formation by 50% relative to controls.
  4. cSI (selective index) was calculated as the ratio of CC50 to IC50.