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Table 2 Summary of included trials comparisons and outcome measures

From: Effectiveness of acupuncture for angina pectoris: a systematic review of randomized controlled trials

Study ID Acupuncture Group (no. of points used) Control Group Treat Duration (days) Outcome measures Outcome Type (Primary/secondary; Subjective/objective)
BALLEGAARD 1986 [35] (A) BA (3 × 2), 20 min/d, 7d as ACOT; plus none (B) Sham acupuncture treatment 21, 3 w follow up Angina attack rate, NTG consumption and general well-being on an ordinal scale Pr4/Se1, 4; Su/Ob
BALLEGAARD 1990 [36] (A) BA (3 × 2), 20 min/d, 10d as ACOT; plus none (B) Sham acupuncture treatment 21, 3 w follow up Angina attack rate, NTG consumption and general well-being on an ordinal scale* Pr4/Se1, 4; Su/Ob
CAO JP 2002 [41] (A) BA G1 (3 + X)a, G2 (3 + X)a, alternate G1 and 2 each time, 20 min/d, 15 d as ACOT; plus (B) (B) ID 5–10 mg Tid, ASP 50–300 mg Tid; BET 25–50 mg Bid and Norvasc 5 mg Qd are chosen according to the disease severity. 15 4 degrees of effects in the symptom; and 3 degrees of effects in the ECG; MID according to DCG Pr4/Se2; Su
CHANG PF 2005 [42] (A) BA G1 (4 × 2 + 2), G2 (4 × 2 + 2), alternate G 1 and 2 every other d, 30 min/d for 14 d; plus none (B) ID 10 mg Tid, or BET 12.5 mg Bid 14 4 degrees of effects in the symptom and ECG; no. Patients of NTG reduction and suspension Pr4/Se2, 4; Su/Ob
DIAO LH 2006 [43] (A) EA (1 + X)a 30 min/d, 6 d and 1 d rest as ACOT; plus none (B) CDP 10 pills (25 mg/pill) Tid 28 4 degrees of effects in the DCG and ECG Se2, 3; Su
(A) EA (1 + X)a 30 min/d, 6 d and 1 d rest as ACOT; plus (B)
HU NK 1997 [44] (A) BA (1 × 2) 30 min/d, 30 d as ACOT; plus (B) (B) Huoxinwan (Chinese medicine) 2 pills Bid, compound Danshen 5 tablets Tid, ASP 50 mg Qd 30 3 degrees of effects in the DCG and ECG Se2, 3; Su
HUANG J 2004 [45] (A) EA (1 × 2) 30 min/d, 6 d per w for 4 ws; plus none (B) CDP 10 pills (25 mg/pill) Tid 28 4 degrees of effects in the symptom and ECG; frequency of attacks, NTG consumption Pr4/Se2, 4; Su/Ob
HUANG J2 2004 [46] (A) EA (1 × 2) 30 min/d, 6 d and 1 d rest as ACOT; plus none (B) CDP 10 pills (25 mg/pill) Tid 28 4 degrees of effects in the symptom and ECG Pr4/Se2; Su
(A) EA (1 × 2) 30 min/d, 6 d and 1 d rest as ACOT; plus (B)
LI CP 2005 [47] (A) BA (10) 25 min/d,12 d and 2 d rest as ACOT; plus (B) (B) ID, ASP, BET used convention 28 3 degrees of effects in the symptom and ECG Pr4/Se2; Su
LI HJ 2003 [48] (A) BA points G1 (3 + X)a, points G1 (3 + X)a, alternate G 1 and 2 every other d, 20 min/d for 2 w; plus (B) (B) CDI 20 ml plus 5% GS or 0.9% NS 250 ml i.v. 28 3 degrees of effects in the symptom and ECG Pr4/Se2; Su
LIU JL 2007 [49] (A) Needle-embedding (2 × 2), 10–15 min/d, 7 d as ACOT; plus (B) (B) ISMN (ISMN)20 mg Bid, simvastatin 10 mg Qd, ASP 75–100 mg Qd. SLNTG 14 3 degrees of effects in the symptom and ECG; no. patients of NTG suspension and reduction Pr4/Se2, 4; Su/Ob
LIU JR 2010 [50] (A) BA (6) 15–20 min/d, 7 d as ACOT; plus none (B) CDP 10 pills (25 mg/pill) Tid, SLNTG 28, 3 m fellow up 3 degrees of effects in the symptom and ECG; NTG consumption Pr4/Se2, 4; Su/Ob
LIU WP 2004 [51] (A) BA (6) 20 min/d, 13 d and 2 d rest as ACOT; plus (B) (B) ID 20 mg Bid, Diltiazem hydrochloride 30 mg Tid, ASP 50 mg Qd. 28 3 degrees of effects in the symptom and ECG Pr4/Se2; Su
LIU WP 2003 [52] (A) BA (5) 20 min/d, 13 d and 1 d rest as ACOT; plus (B) (B) Controlled release ID 20 mg Bid. 56 Quality of life Se1; Su
LIU YF 2012 [53] (A) BA (5 + x)a, 30 min/d; plus none (B) ID 10 mg Tid, ASP 100 mg Qd, BET 12.5 mg Bid, SLNTG 28 4 degrees of effects in the symptom and ECG Pr4/Se2; Su
TONG YH 2005 [54] (A) EA (2 × 2) 20 min/d, 5 d/w for 6 w; plus (B) (B) ASP 150 mg, ISMN 40 mg Qd, BET 25 mg Bid, Zocor 20 mg Qd, SLNTG 42 EF Se7; Ob
WANG PJ 2011 [55] (A) EA (nr) 30 min/d, 6 d/w, alternate bilateral acupoints each time; plus none (B) CDP 10 pills (25 mg/pill) Tid 28 4 degrees of effects in the DCG Se3; Su
(A) EA (nr) 30 min/d, 6 d/w, alternate bilateral acupoints each time; plus (B)
WANG X 2000 [56] (A) BA G1 (5), G2 (5), alternate G 1 and 2 in the morning and afternoon from 1 to 5 d, alternate Groups every other day from 6th day to the end, 30 min/d for 14 d; plus (B) (B) ID or CDI with ASP, NIF, BET 14 3 degrees of effects in the symptom and ECG; duration of angina relief, and angina disappearance Pr4/Se2; Su/Ob
WU CY 2009 [57] (A) BA (3 + 1) 30 min/d, 10 d and 2 d rest as ACOT; plus none (B) CDP 10 pills (25 mg/pill) Tid 34 4 degrees of effects in the symptom; MID according to DCG; no. Patients of NTG reduction and suspension Pr4/Se3, 4; Su/Ob
WU HH 2005 [58] (A) BA (10) 30 min/d for 2 w; plus (B) (B) Nitrates, p.o.; Gegensu injection 500 mg plus 5% GS or 0.85% NS Qd. 14 3 degrees of effects in the symptom; 4 degrees of effects in the ECG Pr4/Se2; Su
XIE ZQ 2003 [59] (A) EA (2 × 2) 20–30 min/d, 12 d and 3 d rest as ACOT; plus (B) (B) ISMN, 10–60 mg, every 4–6 hours; NTG i.v. starts at 5–10 μg/min and increases 5–10 μg per 5 min; NIF 10–20 mg combined with propranlolum 40–80 mg Tid; ASP 0.3-0.6 g Qd; liquaemin injection 5000U, if necessary, 4–6 hours repeated once. 34, a follow up after leaving hospital Cardiovascular events Pr3; Ob
XU GD 2006 [60], TONG YH1 2005 [61] (A) EA (2 × 2) 20 min/d, 5 d and 2 d rest as ACOT; plus (B) (B) ASP 150 mg Qd, ISMN 40 mg Qd, BET 25 mg, Bid, simvastatin 20 mg Qd, SLNTG 42 Quality of life; 3 degrees of effects in the symptom and ECG; onset time of angina relief, angina disappearance Pr4/Se1, 2; Su/Ob
YU W 2006 [62] (A) EA (1 × 2), 30 min/d for 10 d; plus (B) (B) Atenolol 12.5 mg Bid, ASP 100 mg Qd. SLNTG 10 4 degrees of effects in the symptom and ECG; time of angina attack Pr4/Se2; Su/Ob
ZHANG L 2011 [63] (A) BA (6 × 2 + 1) 30 min/d for 4 ws; plus (B) (B) ASP 100 mg, chiralisomer 75 mg, ISMN 20 mg, Perindopril 2 mg, simvastatin 20 mg Qd 28 3 degrees of effects in the symptom and ECG; EF Pr4/Se2, 7; Su/Ob
ZHANG LJ 2005 [64] (A) BA (7) 20 min/d, 10 d and 3 d rest as ACOT; plus none (B) CDP 10 pills (25 mg/pill) Tid 60 4 degrees of effects in the symptom; 3 degrees of effects in the ECG Pr4/Se2; Su
  (A) BA (7) 20 min/d, 10 d and 3 d rest as ACOT; plus (B)
  1. D indicates days; min, minutes; w, week; m, month; BA, Body acupuncture; G, group; EA, electro-acupuncture; ACOT, a course of treatment; ID, Isosorbide dinitrate; CDP, Compound Danshen Pills; ASP, Aspirin; BET, Betaloc; CDI, compound Danshen injection; ISMN, Isosorbide mononitrate; NIF, nifedipine; SLNTG, Sublingual NTG when angina attacks; Pr 4, the 4th primary outcome in the method section, other number as well; Se 2, the 2nd secondary outcome in the method section, other number as well; Su, subjective outcome; Ob, objective outcome; *: much improved, somewhat improved, slightly improved, unchanged, slightly worse, somewhat worse, much worse; MID, myocardial ischemia duration; EF, ejection fraction; ECG: Electrocardiogram; DCG: Dynamic electrocardiogram; Tid: three times daily; Bid: twice daily: Qd: once daily; p.o.: take medicine by oral; i.v.: intravenous injection; NTG: Nitroglycerin; a: The selection of the acupoints according to syndrome differentiation.