Fulvic acid (FA) modulation of homocysteine-induced COX-2 expression is a transcriptional event. U937 cells were transfected with COX-2 p918-Luc promoter plasmid. Cells transfected with p918-Luc that were not stimulated with homocysteine were used as controls (CL). COX-2 promoter activity was measured as fold changes using luciferase assay normalized to β-galactosidase activity from at least three individual experiments. *P < 0.05 versus CL monocytes. #P < 0.05 versus homocysteine-stimulated cells without pretreatment of FA.