From: Cytotoxicity and sub-acute toxicity in Crl:CD (SD) rats of traditional herbal formula Ojeok-san
Dose (mg/kg/day) | 0 | 500 | 1000 | 2000 |
---|---|---|---|---|
Male | ||||
Glucose (mg/dL) | 96.2 ± 28.22 | 100.1 ± 12.23 | 114.6 ± 15.04 | 93.7 ± 10.74 |
BUN (mg/dL) | 13.1 ± 1.73 | 11.2 ± 2.10 | 12.6 ± 0.87 | 13.1 ± 0.61 |
Creatinine (mg/dL) | 0.5 ± 0.03 | 0.5 ± 0.02* | 0.6 ± 0.02 | 0.5 ± 0.03 |
Total protein (g/dL) | 6.5 ± 0.19 | 6.6 ± 0.11 | 6.5 ± 0.09 | 6.2 ± 0.15* |
Albumin (g/dL) | 4.3 ± 0.11 | 4.3 ± 0.06 | 4.2 ± 0.05 | 4.1 ± 0.04 |
Albumin/globulin ratio | 1.9 ± 0.14 | 1.8 ± 0.08 | 1.9 ± 0.05 | 2.0 ± 0.09 |
Total cholesterol (mg/dL) | 54.0 ± 5.92 | 68.2 ± 7.66* | 72.2 ± 12.56** | 60.4 ± 4.22 |
Triglycerides (mg/dL) | 38.6 ± 15.88 | 58.0 ± 19.52 | 47.9 ± 10.78 | 46.8 ± 14.78 |
Phospholipid (mg/dL) | 88 ± 7.90 | 105.0 ± 5.00* | 108.0 ± 13.70** | 93.0 ± 5.00 |
AST (IU/L) | 130.3 ± 21.37 | 111.7 ± 17.16 | 114.0 ± 9.78 | 118.7 ± 26.26 |
ALT (IU/L) | 32.6 ± 4.59 | 33.3 ± 4.18 | 34.3 ± 4.78 | 38.8 ± 2.35 |
Total bilirubin (mg/dL) | 0.2 ± 0.02 | 0.1 ± 0.01 | 0.1 ± 0.01 | 0.1 ± 0.00 |
ALP (IU/L) | 452.1 ± 54.40 | 472.9 ± 97.97 | 450.7 ± 50.77 | 422.1 ± 31.08 |
Creatine kinase (IU/L) | 736.0 ± 249.90 | 551.0 ± 204.30 | 587.0 ± 113.40 | 665.0 ± 363.60 |
Ca (mg/dL) | 10.9 ± 0.44 | 11.2 ± 0.22 | 11.5 ± 0.18 | 11.2 ± 0.53 |
IP (mg/dL) | 10.8 ± 0.96 | 10.9 ± 0.42 | 10.7 ± 0.49 | 11.1 ± 0.73 |
Na (mmol/L) | 146.0 ± 1.60 | 146.0 ± 0.90 | 146.0 ± 0.80 | 147.0 ± 1.50 |
K (mmol/L) | 7.47 ± 1.57 | 8.7 ± 0.61 | 8.6 ± 0.52 | 7.6 ± 0.84 |
Cl (mmol/L) | 103.0 ± 1.30 | 100.0 ± 0.90* | 102.0 ± 1.60 | 102.0 ± 0.50 |
GGT (IU/L) | 0.8 ± 0.33 | 1.2 ± 0.62 | 0.7 ± 0.38 | 0.5 ± 0.44 |
Female | ||||
Glucose (mg/dL) | 94.2 ± 16.57 | 90.7 ± 22.27 | 112.5 ± 47.45 | 86.8 ± 27.31 |
BUN (mg/dL) | 17.4 ± 2.46 | 17.7 ± 2.90 | 16.7 ± 2.42 | 18.9 ± 3.47 |
Creatinine (mg/dL) | 0.6 ± 0.05 | 0.6 ± 0.03 | 0.6 ± 0.07 | 0.6 ± 0.05 |
Total protein (g/dL) | 6.9 ± 0.43 | 6.9 ± 0.28 | 7.0 ± 0.25 | 7.0 ± 0.18 |
Albumin (g/dL) | 4.5 ± 0.30 | 4.6 ± 0.15 | 4.6 ± 0.20 | 4.6 ± 0.11 |
Albumin/globulin ratio | 1.9 ± 0.08 | 2.0 ± 0.08 | 1.91 ± 0.1 | 2.0 ± 0.11 |
Total cholesterol (mg/dL) | 80.6 ± 13.94 | 72.2 ± 12.60 | 62.6 ± 17.73 | 76.0 ± 12.90 |
Triglycerides (mg/dL) | 41.6 ± 14.10 | 29.4 ± 3.39 | 25.0 ± 1.88* | 26.4 ± 4.80 |
Phospholipid (mg/dL) | 141.0 ± 22.70 | 126.0 ± 18.50 | 112.0 ± 20.40 | 128.0 ± 17.00 |
AST (IU/L) | 110.2 ± 12.78 | 112.2 ± 20.95 | 110.6 ± 18.88 | 119.6 ± 21.56 |
ALT (IU/L) | 26.7 ± 4.12 | 28.3 ± 4.46 | 28.9 ± 4.90 | 29.4 ± 4.51 |
Total bilirubin (mg/dL) | 0.1 ± 0.01 | 0.1 ± 0.01 | 0.1 ± 0.03 | 0.1 ± 0.02 |
ALP (IU/L) | 238.6 ± 37.60 | 266.7 ± 59.82 | 270.0 ± 67.43 | 254.9 ± 38.56 |
Creatine kinase (IU/L) | 580.0 ± 140.90 | 547.0 ± 169.30 | 408.0 ± 76.30 | 656.0 ± 204.00 |
Ca (mg/dL) | 11.9 ± 0.12 | 11.6 ± 0.55 | 11.5 ± 0.39 | 11.2 ± 0.22 |
IP (mg/dL) | 10.7 ± 0.65 | 10.2 ± 0.56 | 10.0 ± 0.90 | 10.1 ± 0.41 |
Na (mmol/L) | 145.0 ± 0.80 | 145.0 ± 1.80 | 145.0 ± 0.50 | 144.0 ± 1.10 |
K (mmol/L) | 7.9 ± 0.76 | 7.7 ± 0.54 | 7.5 ± 0.46 | 7.9 ± 0.79 |
Cl (mmol/L) | 102.0 ± 1.20 | 103.0 ± 1.50 | 103.0 ± 1.10 | 102.0 ± 0.80 |
GGT (IU/L) | 1.5 ± 0.70 | 1.2 ± 0.66 | 1.7 ± 0.53 | 1.3 ± 0.57 |