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Table 4 Serum biochemical values of animals treated with OJS for 4 weeks

From: Cytotoxicity and sub-acute toxicity in Crl:CD (SD) rats of traditional herbal formula Ojeok-san

Dose (mg/kg/day) 0 500 1000 2000
Male     
Glucose (mg/dL) 96.2 ± 28.22 100.1 ± 12.23 114.6 ± 15.04 93.7 ± 10.74
BUN (mg/dL) 13.1 ± 1.73 11.2 ± 2.10 12.6 ± 0.87 13.1 ± 0.61
Creatinine (mg/dL) 0.5 ± 0.03 0.5 ± 0.02* 0.6 ± 0.02 0.5 ± 0.03
Total protein (g/dL) 6.5 ± 0.19 6.6 ± 0.11 6.5 ± 0.09 6.2 ± 0.15*
Albumin (g/dL) 4.3 ± 0.11 4.3 ± 0.06 4.2 ± 0.05 4.1 ± 0.04
Albumin/globulin ratio 1.9 ± 0.14 1.8 ± 0.08 1.9 ± 0.05 2.0 ± 0.09
Total cholesterol (mg/dL) 54.0 ± 5.92 68.2 ± 7.66* 72.2 ± 12.56** 60.4 ± 4.22
Triglycerides (mg/dL) 38.6 ± 15.88 58.0 ± 19.52 47.9 ± 10.78 46.8 ± 14.78
Phospholipid (mg/dL) 88 ± 7.90 105.0 ± 5.00* 108.0 ± 13.70** 93.0 ± 5.00
AST (IU/L) 130.3 ± 21.37 111.7 ± 17.16 114.0 ± 9.78 118.7 ± 26.26
ALT (IU/L) 32.6 ± 4.59 33.3 ± 4.18 34.3 ± 4.78 38.8 ± 2.35
Total bilirubin (mg/dL) 0.2 ± 0.02 0.1 ± 0.01 0.1 ± 0.01 0.1 ± 0.00
ALP (IU/L) 452.1 ± 54.40 472.9 ± 97.97 450.7 ± 50.77 422.1 ± 31.08
Creatine kinase (IU/L) 736.0 ± 249.90 551.0 ± 204.30 587.0 ± 113.40 665.0 ± 363.60
Ca (mg/dL) 10.9 ± 0.44 11.2 ± 0.22 11.5 ± 0.18 11.2 ± 0.53
IP (mg/dL) 10.8 ± 0.96 10.9 ± 0.42 10.7 ± 0.49 11.1 ± 0.73
Na (mmol/L) 146.0 ± 1.60 146.0 ± 0.90 146.0 ± 0.80 147.0 ± 1.50
K (mmol/L) 7.47 ± 1.57 8.7 ± 0.61 8.6 ± 0.52 7.6 ± 0.84
Cl (mmol/L) 103.0 ± 1.30 100.0 ± 0.90* 102.0 ± 1.60 102.0 ± 0.50
GGT (IU/L) 0.8 ± 0.33 1.2 ± 0.62 0.7 ± 0.38 0.5 ± 0.44
Female     
Glucose (mg/dL) 94.2 ± 16.57 90.7 ± 22.27 112.5 ± 47.45 86.8 ± 27.31
BUN (mg/dL) 17.4 ± 2.46 17.7 ± 2.90 16.7 ± 2.42 18.9 ± 3.47
Creatinine (mg/dL) 0.6 ± 0.05 0.6 ± 0.03 0.6 ± 0.07 0.6 ± 0.05
Total protein (g/dL) 6.9 ± 0.43 6.9 ± 0.28 7.0 ± 0.25 7.0 ± 0.18
Albumin (g/dL) 4.5 ± 0.30 4.6 ± 0.15 4.6 ± 0.20 4.6 ± 0.11
Albumin/globulin ratio 1.9 ± 0.08 2.0 ± 0.08 1.91 ± 0.1 2.0 ± 0.11
Total cholesterol (mg/dL) 80.6 ± 13.94 72.2 ± 12.60 62.6 ± 17.73 76.0 ± 12.90
Triglycerides (mg/dL) 41.6 ± 14.10 29.4 ± 3.39 25.0 ± 1.88* 26.4 ± 4.80
Phospholipid (mg/dL) 141.0 ± 22.70 126.0 ± 18.50 112.0 ± 20.40 128.0 ± 17.00
AST (IU/L) 110.2 ± 12.78 112.2 ± 20.95 110.6 ± 18.88 119.6 ± 21.56
ALT (IU/L) 26.7 ± 4.12 28.3 ± 4.46 28.9 ± 4.90 29.4 ± 4.51
Total bilirubin (mg/dL) 0.1 ± 0.01 0.1 ± 0.01 0.1 ± 0.03 0.1 ± 0.02
ALP (IU/L) 238.6 ± 37.60 266.7 ± 59.82 270.0 ± 67.43 254.9 ± 38.56
Creatine kinase (IU/L) 580.0 ± 140.90 547.0 ± 169.30 408.0 ± 76.30 656.0 ± 204.00
Ca (mg/dL) 11.9 ± 0.12 11.6 ± 0.55 11.5 ± 0.39 11.2 ± 0.22
IP (mg/dL) 10.7 ± 0.65 10.2 ± 0.56 10.0 ± 0.90 10.1 ± 0.41
Na (mmol/L) 145.0 ± 0.80 145.0 ± 1.80 145.0 ± 0.50 144.0 ± 1.10
K (mmol/L) 7.9 ± 0.76 7.7 ± 0.54 7.5 ± 0.46 7.9 ± 0.79
Cl (mmol/L) 102.0 ± 1.20 103.0 ± 1.50 103.0 ± 1.10 102.0 ± 0.80
GGT (IU/L) 1.5 ± 0.70 1.2 ± 0.66 1.7 ± 0.53 1.3 ± 0.57
  1. ALP, alkaline phosphatase; AST, aspartate aminotransferase; ALT, alkaline phosphatase; BUN, blood urea nitrogen.
  2. Values are presented as mean ± SD.
  3. * and ** indicate significant difference at p < 0.05 and p < 0.01 levels, respectively, when compared with the vehicle control group.