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Table 4 Serum biochemical values of animals treated with OJS for 4 weeks

From: Cytotoxicity and sub-acute toxicity in Crl:CD (SD) rats of traditional herbal formula Ojeok-san

Dose (mg/kg/day)

0

500

1000

2000

Male

    

Glucose (mg/dL)

96.2 ± 28.22

100.1 ± 12.23

114.6 ± 15.04

93.7 ± 10.74

BUN (mg/dL)

13.1 ± 1.73

11.2 ± 2.10

12.6 ± 0.87

13.1 ± 0.61

Creatinine (mg/dL)

0.5 ± 0.03

0.5 ± 0.02*

0.6 ± 0.02

0.5 ± 0.03

Total protein (g/dL)

6.5 ± 0.19

6.6 ± 0.11

6.5 ± 0.09

6.2 ± 0.15*

Albumin (g/dL)

4.3 ± 0.11

4.3 ± 0.06

4.2 ± 0.05

4.1 ± 0.04

Albumin/globulin ratio

1.9 ± 0.14

1.8 ± 0.08

1.9 ± 0.05

2.0 ± 0.09

Total cholesterol (mg/dL)

54.0 ± 5.92

68.2 ± 7.66*

72.2 ± 12.56**

60.4 ± 4.22

Triglycerides (mg/dL)

38.6 ± 15.88

58.0 ± 19.52

47.9 ± 10.78

46.8 ± 14.78

Phospholipid (mg/dL)

88 ± 7.90

105.0 ± 5.00*

108.0 ± 13.70**

93.0 ± 5.00

AST (IU/L)

130.3 ± 21.37

111.7 ± 17.16

114.0 ± 9.78

118.7 ± 26.26

ALT (IU/L)

32.6 ± 4.59

33.3 ± 4.18

34.3 ± 4.78

38.8 ± 2.35

Total bilirubin (mg/dL)

0.2 ± 0.02

0.1 ± 0.01

0.1 ± 0.01

0.1 ± 0.00

ALP (IU/L)

452.1 ± 54.40

472.9 ± 97.97

450.7 ± 50.77

422.1 ± 31.08

Creatine kinase (IU/L)

736.0 ± 249.90

551.0 ± 204.30

587.0 ± 113.40

665.0 ± 363.60

Ca (mg/dL)

10.9 ± 0.44

11.2 ± 0.22

11.5 ± 0.18

11.2 ± 0.53

IP (mg/dL)

10.8 ± 0.96

10.9 ± 0.42

10.7 ± 0.49

11.1 ± 0.73

Na (mmol/L)

146.0 ± 1.60

146.0 ± 0.90

146.0 ± 0.80

147.0 ± 1.50

K (mmol/L)

7.47 ± 1.57

8.7 ± 0.61

8.6 ± 0.52

7.6 ± 0.84

Cl (mmol/L)

103.0 ± 1.30

100.0 ± 0.90*

102.0 ± 1.60

102.0 ± 0.50

GGT (IU/L)

0.8 ± 0.33

1.2 ± 0.62

0.7 ± 0.38

0.5 ± 0.44

Female

    

Glucose (mg/dL)

94.2 ± 16.57

90.7 ± 22.27

112.5 ± 47.45

86.8 ± 27.31

BUN (mg/dL)

17.4 ± 2.46

17.7 ± 2.90

16.7 ± 2.42

18.9 ± 3.47

Creatinine (mg/dL)

0.6 ± 0.05

0.6 ± 0.03

0.6 ± 0.07

0.6 ± 0.05

Total protein (g/dL)

6.9 ± 0.43

6.9 ± 0.28

7.0 ± 0.25

7.0 ± 0.18

Albumin (g/dL)

4.5 ± 0.30

4.6 ± 0.15

4.6 ± 0.20

4.6 ± 0.11

Albumin/globulin ratio

1.9 ± 0.08

2.0 ± 0.08

1.91 ± 0.1

2.0 ± 0.11

Total cholesterol (mg/dL)

80.6 ± 13.94

72.2 ± 12.60

62.6 ± 17.73

76.0 ± 12.90

Triglycerides (mg/dL)

41.6 ± 14.10

29.4 ± 3.39

25.0 ± 1.88*

26.4 ± 4.80

Phospholipid (mg/dL)

141.0 ± 22.70

126.0 ± 18.50

112.0 ± 20.40

128.0 ± 17.00

AST (IU/L)

110.2 ± 12.78

112.2 ± 20.95

110.6 ± 18.88

119.6 ± 21.56

ALT (IU/L)

26.7 ± 4.12

28.3 ± 4.46

28.9 ± 4.90

29.4 ± 4.51

Total bilirubin (mg/dL)

0.1 ± 0.01

0.1 ± 0.01

0.1 ± 0.03

0.1 ± 0.02

ALP (IU/L)

238.6 ± 37.60

266.7 ± 59.82

270.0 ± 67.43

254.9 ± 38.56

Creatine kinase (IU/L)

580.0 ± 140.90

547.0 ± 169.30

408.0 ± 76.30

656.0 ± 204.00

Ca (mg/dL)

11.9 ± 0.12

11.6 ± 0.55

11.5 ± 0.39

11.2 ± 0.22

IP (mg/dL)

10.7 ± 0.65

10.2 ± 0.56

10.0 ± 0.90

10.1 ± 0.41

Na (mmol/L)

145.0 ± 0.80

145.0 ± 1.80

145.0 ± 0.50

144.0 ± 1.10

K (mmol/L)

7.9 ± 0.76

7.7 ± 0.54

7.5 ± 0.46

7.9 ± 0.79

Cl (mmol/L)

102.0 ± 1.20

103.0 ± 1.50

103.0 ± 1.10

102.0 ± 0.80

GGT (IU/L)

1.5 ± 0.70

1.2 ± 0.66

1.7 ± 0.53

1.3 ± 0.57

  1. ALP, alkaline phosphatase; AST, aspartate aminotransferase; ALT, alkaline phosphatase; BUN, blood urea nitrogen.
  2. Values are presented as mean ± SD.
  3. * and ** indicate significant difference at p < 0.05 and p < 0.01 levels, respectively, when compared with the vehicle control group.