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Table 3 Hematological values of animals treated with OJS for 4 weeks

From: Cytotoxicity and sub-acute toxicity in Crl:CD (SD) rats of traditional herbal formula Ojeok-san

Dose (mg/kg/day)

0

500

1000

2000

Male

    

WBC (103/μL)

10.1 ± 3.32

10.2 ± 4.00

10.3 ± 1.05

9.8 ± 1.09

Reticulocyte (%)

2.6 ± 0.57

2.5 ± 0.30

2.5 ± 0.30

2.3 ± 0.34

Neutrophils (%)

16.0 ± 5.16

12.1 ± 4.42

11.2 ± 1.92

11.0 ± 3.17

Lymphocytes (%)

77.3 ± 5.76

82.4 ± 5.65

83.1 ± 2.03

82.0 ± 3.57

Eosinophils (%)

0.9 ± 0.23

0.7 ± 0.36

0.6 ± 0.13

0.9 ± 0.26

Monocytes (%)

3.5 ± 1.11

2.6 ± 1.07

3.0 ± 0.59

3.8 ± 0.77

Basophils (%)

1.0 ± 0.38

0.9 ± 0.40

1.0 ± 0.45

0.8 ± 0.23

Large unstained cells (%)

1.3 ± 0.40

1.2 ± 0.26

1.1 ± 0.11

1.5 ± 0.27

RBC (106/μL)

7.9 ± 0.27

8.0 ± 0.12

8.2 ± 0.40

8.0 ± 0.38

Hemoglobin (g/dl)

15.7 ± 0.46

16.0 ± 0.35

16.3 ± 0.71

15.6 ± 0.64

Hematocrit (%)

46.2 ± 1.07

46.4 ± 1.10

47.7 ± 1.90

46.0 ± 1.93

MCV (fL)

58.7 ± 1.88

58.0 ± 0.56

58.3 ± 1.59

57.5 ± 1.37

MCH (pg)

19.9 ± 0.41

19.9 ± 0.27

19.9 ± 0.74

19.5 ± 0.45

MCHC (g/dl)

34.0 ± 0.63

34.4 ± 0.39

34.1 ± 0.65

33.9 ± 0.13

Platelet (103/μL)

1113.0 ± 124.70

1195.0 ± 197.00

1074.0 ± 129.80

1155.0 ± 65.60

Female

    

WBC (103/μL)

11.5 ± 1.36

9.4 ± 2.39

8.0 ± 1.60*

6.4 ± 0.93**

Reticulocyte (%)

2.1 ± 0.16

2.1 ± 0.16

2.0 ± 0.53

2.2 ± 0.28

Neutrophils (%)

12.3 ± 4.32

12.3 ± 4.32

9.6 ± 2.54

11.1 ± 4.56

Lymphocytes (%)

81.8 ± 4.37

84.3 ± 4.58

84.4 ± 2.22

82.8 ± 4.28

Eosinophils (%)

0.3 ± 0.24

0.7 ± 0.15

0.7 ± 0.26

0.8 ± 0.20

Monocytes (%)

2.9 ± 0.70

3.3 ± 0.69

3.0 ± 1.12

3.0 ± 1.48

Basophils (%)

1.1 ± 0.54

1.2 ± 0.31

1.1 ± 0.39

1.2 ± 0.39

Large unstained cells (%)

1.0 ± 0.22

1.2 ± 0.34

1.2 ± 0.36

1.1 ± 0.26

RBC (106/μL)

8.1 ± 0.36

8.3 ± 0.26

8.0 ± 0.22

8.1 ± 0.44

Hemoglobin (g/dl)

16.2 ± 0.51

16.5 ± 0.29

15.8 ± 0.43

16.4 ± 0.42

Hematocrit (%)

46.4 ± 1.76

47.3 ± 1.09

45.9 ± 0.86

47.2 ± 2.15

MCV (fL)

57.6 ± 0.64

56.8 ± 0.79

57.7 ± 1.92

58.2 ± 1.68

MCH (pg)

20.1 ± 0.35

19.8 ± 0.37

19.8 ± 0.76

20.4 ± 0.64

MCHC (g/dl)

34.9 ± 0.61

34.9 ± 0.30

34.4 ± 0.38

34.9 ± 0.85

Platelet (103/μL)

1169.0 ± 86.40

1168.0 ± 91.10

1297.0 ± 85.10

1199.0 ± 184.20

  1. MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; PT, prothrombin time.
  2. Values are presented as mean ± SD.
  3. * and ** indicates a significant difference at p < 0.05 and p < 0.01 level, respectively, when compared with the vehicle control group.