From: Cytotoxicity and sub-acute toxicity in Crl:CD (SD) rats of traditional herbal formula Ojeok-san
Dose (mg/kg/day) | 0 | 500 | 1000 | 2000 |
---|---|---|---|---|
Male | ||||
WBC (103/μL) | 10.1 ± 3.32 | 10.2 ± 4.00 | 10.3 ± 1.05 | 9.8 ± 1.09 |
Reticulocyte (%) | 2.6 ± 0.57 | 2.5 ± 0.30 | 2.5 ± 0.30 | 2.3 ± 0.34 |
Neutrophils (%) | 16.0 ± 5.16 | 12.1 ± 4.42 | 11.2 ± 1.92 | 11.0 ± 3.17 |
Lymphocytes (%) | 77.3 ± 5.76 | 82.4 ± 5.65 | 83.1 ± 2.03 | 82.0 ± 3.57 |
Eosinophils (%) | 0.9 ± 0.23 | 0.7 ± 0.36 | 0.6 ± 0.13 | 0.9 ± 0.26 |
Monocytes (%) | 3.5 ± 1.11 | 2.6 ± 1.07 | 3.0 ± 0.59 | 3.8 ± 0.77 |
Basophils (%) | 1.0 ± 0.38 | 0.9 ± 0.40 | 1.0 ± 0.45 | 0.8 ± 0.23 |
Large unstained cells (%) | 1.3 ± 0.40 | 1.2 ± 0.26 | 1.1 ± 0.11 | 1.5 ± 0.27 |
RBC (106/μL) | 7.9 ± 0.27 | 8.0 ± 0.12 | 8.2 ± 0.40 | 8.0 ± 0.38 |
Hemoglobin (g/dl) | 15.7 ± 0.46 | 16.0 ± 0.35 | 16.3 ± 0.71 | 15.6 ± 0.64 |
Hematocrit (%) | 46.2 ± 1.07 | 46.4 ± 1.10 | 47.7 ± 1.90 | 46.0 ± 1.93 |
MCV (fL) | 58.7 ± 1.88 | 58.0 ± 0.56 | 58.3 ± 1.59 | 57.5 ± 1.37 |
MCH (pg) | 19.9 ± 0.41 | 19.9 ± 0.27 | 19.9 ± 0.74 | 19.5 ± 0.45 |
MCHC (g/dl) | 34.0 ± 0.63 | 34.4 ± 0.39 | 34.1 ± 0.65 | 33.9 ± 0.13 |
Platelet (103/μL) | 1113.0 ± 124.70 | 1195.0 ± 197.00 | 1074.0 ± 129.80 | 1155.0 ± 65.60 |
Female | ||||
WBC (103/μL) | 11.5 ± 1.36 | 9.4 ± 2.39 | 8.0 ± 1.60* | 6.4 ± 0.93** |
Reticulocyte (%) | 2.1 ± 0.16 | 2.1 ± 0.16 | 2.0 ± 0.53 | 2.2 ± 0.28 |
Neutrophils (%) | 12.3 ± 4.32 | 12.3 ± 4.32 | 9.6 ± 2.54 | 11.1 ± 4.56 |
Lymphocytes (%) | 81.8 ± 4.37 | 84.3 ± 4.58 | 84.4 ± 2.22 | 82.8 ± 4.28 |
Eosinophils (%) | 0.3 ± 0.24 | 0.7 ± 0.15 | 0.7 ± 0.26 | 0.8 ± 0.20 |
Monocytes (%) | 2.9 ± 0.70 | 3.3 ± 0.69 | 3.0 ± 1.12 | 3.0 ± 1.48 |
Basophils (%) | 1.1 ± 0.54 | 1.2 ± 0.31 | 1.1 ± 0.39 | 1.2 ± 0.39 |
Large unstained cells (%) | 1.0 ± 0.22 | 1.2 ± 0.34 | 1.2 ± 0.36 | 1.1 ± 0.26 |
RBC (106/μL) | 8.1 ± 0.36 | 8.3 ± 0.26 | 8.0 ± 0.22 | 8.1 ± 0.44 |
Hemoglobin (g/dl) | 16.2 ± 0.51 | 16.5 ± 0.29 | 15.8 ± 0.43 | 16.4 ± 0.42 |
Hematocrit (%) | 46.4 ± 1.76 | 47.3 ± 1.09 | 45.9 ± 0.86 | 47.2 ± 2.15 |
MCV (fL) | 57.6 ± 0.64 | 56.8 ± 0.79 | 57.7 ± 1.92 | 58.2 ± 1.68 |
MCH (pg) | 20.1 ± 0.35 | 19.8 ± 0.37 | 19.8 ± 0.76 | 20.4 ± 0.64 |
MCHC (g/dl) | 34.9 ± 0.61 | 34.9 ± 0.30 | 34.4 ± 0.38 | 34.9 ± 0.85 |
Platelet (103/μL) | 1169.0 ± 86.40 | 1168.0 ± 91.10 | 1297.0 ± 85.10 | 1199.0 ± 184.20 |