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Table 3 Hematological values of animals treated with OJS for 4 weeks

From: Cytotoxicity and sub-acute toxicity in Crl:CD (SD) rats of traditional herbal formula Ojeok-san

Dose (mg/kg/day) 0 500 1000 2000
Male     
WBC (103/μL) 10.1 ± 3.32 10.2 ± 4.00 10.3 ± 1.05 9.8 ± 1.09
Reticulocyte (%) 2.6 ± 0.57 2.5 ± 0.30 2.5 ± 0.30 2.3 ± 0.34
Neutrophils (%) 16.0 ± 5.16 12.1 ± 4.42 11.2 ± 1.92 11.0 ± 3.17
Lymphocytes (%) 77.3 ± 5.76 82.4 ± 5.65 83.1 ± 2.03 82.0 ± 3.57
Eosinophils (%) 0.9 ± 0.23 0.7 ± 0.36 0.6 ± 0.13 0.9 ± 0.26
Monocytes (%) 3.5 ± 1.11 2.6 ± 1.07 3.0 ± 0.59 3.8 ± 0.77
Basophils (%) 1.0 ± 0.38 0.9 ± 0.40 1.0 ± 0.45 0.8 ± 0.23
Large unstained cells (%) 1.3 ± 0.40 1.2 ± 0.26 1.1 ± 0.11 1.5 ± 0.27
RBC (106/μL) 7.9 ± 0.27 8.0 ± 0.12 8.2 ± 0.40 8.0 ± 0.38
Hemoglobin (g/dl) 15.7 ± 0.46 16.0 ± 0.35 16.3 ± 0.71 15.6 ± 0.64
Hematocrit (%) 46.2 ± 1.07 46.4 ± 1.10 47.7 ± 1.90 46.0 ± 1.93
MCV (fL) 58.7 ± 1.88 58.0 ± 0.56 58.3 ± 1.59 57.5 ± 1.37
MCH (pg) 19.9 ± 0.41 19.9 ± 0.27 19.9 ± 0.74 19.5 ± 0.45
MCHC (g/dl) 34.0 ± 0.63 34.4 ± 0.39 34.1 ± 0.65 33.9 ± 0.13
Platelet (103/μL) 1113.0 ± 124.70 1195.0 ± 197.00 1074.0 ± 129.80 1155.0 ± 65.60
Female     
WBC (103/μL) 11.5 ± 1.36 9.4 ± 2.39 8.0 ± 1.60* 6.4 ± 0.93**
Reticulocyte (%) 2.1 ± 0.16 2.1 ± 0.16 2.0 ± 0.53 2.2 ± 0.28
Neutrophils (%) 12.3 ± 4.32 12.3 ± 4.32 9.6 ± 2.54 11.1 ± 4.56
Lymphocytes (%) 81.8 ± 4.37 84.3 ± 4.58 84.4 ± 2.22 82.8 ± 4.28
Eosinophils (%) 0.3 ± 0.24 0.7 ± 0.15 0.7 ± 0.26 0.8 ± 0.20
Monocytes (%) 2.9 ± 0.70 3.3 ± 0.69 3.0 ± 1.12 3.0 ± 1.48
Basophils (%) 1.1 ± 0.54 1.2 ± 0.31 1.1 ± 0.39 1.2 ± 0.39
Large unstained cells (%) 1.0 ± 0.22 1.2 ± 0.34 1.2 ± 0.36 1.1 ± 0.26
RBC (106/μL) 8.1 ± 0.36 8.3 ± 0.26 8.0 ± 0.22 8.1 ± 0.44
Hemoglobin (g/dl) 16.2 ± 0.51 16.5 ± 0.29 15.8 ± 0.43 16.4 ± 0.42
Hematocrit (%) 46.4 ± 1.76 47.3 ± 1.09 45.9 ± 0.86 47.2 ± 2.15
MCV (fL) 57.6 ± 0.64 56.8 ± 0.79 57.7 ± 1.92 58.2 ± 1.68
MCH (pg) 20.1 ± 0.35 19.8 ± 0.37 19.8 ± 0.76 20.4 ± 0.64
MCHC (g/dl) 34.9 ± 0.61 34.9 ± 0.30 34.4 ± 0.38 34.9 ± 0.85
Platelet (103/μL) 1169.0 ± 86.40 1168.0 ± 91.10 1297.0 ± 85.10 1199.0 ± 184.20
  1. MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; PT, prothrombin time.
  2. Values are presented as mean ± SD.
  3. * and ** indicates a significant difference at p < 0.05 and p < 0.01 level, respectively, when compared with the vehicle control group.