From: Cytotoxicity and sub-acute toxicity in Crl:CD (SD) rats of traditional herbal formula Ojeok-san
Dose (mg/kg/day) | 0 | 500 | 1000 | 2000 |
---|---|---|---|---|
Male | ||||
Brain | 1.966 ± 0.0689 | 2.036 ± 0.0512 | 1.922 ± 0.0454 | 1.975 ± 0.0695 |
Pituitary gland | 0.010 ± 0.0017 | 0.010 ± 0.0020 | 0.011 ± 0.0032 | 0.011 ± 0.0012 |
Liver | 11.204 ± 0.7302 | 12.838 ± 0.7539 | 10.520 ± 0.9710 | 10.789 ± 0.6777 |
Spleen | 0.720 ± 0.0892 | 0.716 ± 0.0400 | 0.638 ± 0.0786 | 0.711 ± 0.1093 |
Heart | 1.225 ± 0.0835 | 1.138 ± 0.0591 | 1.096 ± 0.1013 | 1.194 ± 0.0311 |
Thymus | 0.570 ± 0.0916 | 0.553 ± 0.1395 | 0.544 ± 0.0761 | 0.549 ± 0.1076 |
Salivary glands | 0.604 ± 0.0415 | 0.572 ± 0.0318 | 0.548 ± 0.0415 | 0.605 ± 0.0289 |
Seminal vesicle | 1.124 ± 0.1204 | 0.956 ± 0.3066 | 0.890 ± 0.2533 | 0.986 ± 0.1801 |
Prostate | 0.432 ± 0.0821 | 0.371 ± 0.0599 | 0.445 ± 0.0568 | 0.464 ± 0.0810 |
Kidneys | 2.934 ± 0.2372 | 3.117 ± 0.1676 | 2.803 ± 0.2866 | 2.947 ± 0.2479 |
Adrenal glands | 0.054 ± 0.0069 | 0.062 ± 0.0098 | 0.055 ± 0.0022 | 0.055 ± 0.0079 |
Testes | 3.079 ± 0.1499 | 3.043 ± 0.1776 | 2.952 ± 0.1368 | 2.845 ± 0.5047 |
Epididymides | 0.896 ± 0.0475 | 0.880 ± 0.0445 | 0.840 ± 0.0445 | 0.862 ± 0.1289 |
Lung | 1.357 ± 0.1520 | 1.473 ± 0.1236 | 1.322 ± 0.0734 | 1.377 ± 0.1054 |
Thyroid/Parathyroid | 0.019 ± 0.0038 | 0.020 ± 0.0034 | 0.017 ± 0.0028 | 0.018 ± 0.0023 |
Female | ||||
Brain | 1.851 ± 0.0776 | 1.840 ± 0.0889 | 1.815 ± 0.0668 | 1.833 ± 0.0563 |
Pituitary gland | 0.012 ± 0.0025 | 0.014 ± 0.0015 | 0.014 ± 0.0028 | 0.010 ± 0.0023 |
Liver | 7.367 ± 0.4526 | 7.096 ± 0.6750 | 7.435 ± 0.8109 | 8.006 ± 0.2126 |
Spleen | 0.540 ± 0.0879 | 0.499 ± 0.0512 | 0.483 ± 0.0537 | 0.474 ± 0.0788 |
Heart | 0.807 ± 0.0278 | 0.762 ± 0.0647 | 0.820 ± 0.0831 | 0.833 ± 0.0316 |
Thymus | 0.545 ± 0.1480 | 0.491 ± 0.0715 | 0.426 ± 0.0483 | 0.467 ± 0.0627 |
Salivary glands | 0.412 ± 0.0221 | 0.387 ± 0.0280 | 0.403 ± 0.0293 | 0.410 ± 0.0266 |
Kidneys | 1.807 ± 0.1272 | 1.877 ± 0.1172 | 1.930 ± 0.2121 | 1.885 ± 0.0786 |
Adrenal glands | 0.074 ± 0.0087 | 0.070 ± 0.0118 | 0.077 ± 0.0127 | 0.070 ± 0.0122 |
Ovaries | 0.084 ± 0.0104 | 0.076 ± 0.0070 | 0.093 ± 0.149 | 0.094 ± 0.0171 |
Lung | 1.102 ± 0.0369 | 1.039 ± 0.0994 | 1.069 ± 0.1336 | 1.098 ± 0.0551 |
Thyroid/parathyroid | 0.014 ± 0.0021 | 0.016 ± 0.0048 | 0.016 ± 0.0036 | 0.017 ± 0.0021 |
Uterus/cervix | 0.451 ± 0.1435 | 0.409 ± 0.1121 | 0.576 ± 0.1598 | 0.458 ± 0.0742 |