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Table 8 Exact MICs (μg/ml) of antibiotics with flavonoid/(s) against S. aureus (ATCC 43300) and clinical isolates of MRSA

From: Antibiotic additive and synergistic action of rutin, morin and quercetin against methicillin resistant Staphylococcus aureus

 

Antibiotic alone

With M + R

With Q

With M + R + Q

AMO †

256

64 ♣

256

8

AMO *

197.70a ± 64.02

49.43a ± 16.03

197.70a ± 64.02

6.00a ± 2.13

MIC range*

128 – 256

32 - 64

128 - 256

2-8

AMP †

128

128

16

4

AMP *

162.85a ± 68.05

162.85a ± 68.05

20.36a ± 8.51

5.09a ± 2.13

MIC range*

64 – 256

64 - 256

8-32

2-8

CEPH†

256

64

32

8

CEPH*

200.96 a ± 63.69

50.38 a ± 17.92

25.12a ± 7.92

6.28a ± 1.99

MIC range*

128 – 256

32 - 64

16 - 32

4-8

CET †

64

16

8

2

CET*

67.52 a ± 30.48

27.09 a ± 16.94

8.44a ± 3.81

2.11a ± 0.95

MIC range*

32 – 128

16 - 64

4 - 16

1-4

IMP †

32

8

4

1

IMP*

130.88 a ± 84.02

32.72 a ± 16.15

19.88a ± 10.51

4.97a ± 2.63

MIC range*

32 – 256

8 - 64

4 - 32

1-8

ME †

64

16

8

2

ME*

135.68 a ± 54.03

33.92 a ± 13.51

16.96a ± 6.75

4.24a ± 1.69

MIC range*

64 – 256

16 - 64

8 - 32

2-8

  1. ♣MIC of M & R is same.
  2. a= Average value.
  3. *against MRSA clinical isolates (n = 100).
  4. † against S. aureus (ATCC 43300).