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Table 8 Exact MICs (μg/ml) of antibiotics with flavonoid/(s) against S. aureus (ATCC 43300) and clinical isolates of MRSA

From: Antibiotic additive and synergistic action of rutin, morin and quercetin against methicillin resistant Staphylococcus aureus

  Antibiotic alone With M + R With Q With M + R + Q
AMO † 256 64 256 8
AMO * 197.70a ± 64.02 49.43a ± 16.03 197.70a ± 64.02 6.00a ± 2.13
MIC range* 128 – 256 32 - 64 128 - 256 2-8
AMP † 128 128 16 4
AMP * 162.85a ± 68.05 162.85a ± 68.05 20.36a ± 8.51 5.09a ± 2.13
MIC range* 64 – 256 64 - 256 8-32 2-8
CEPH† 256 64 32 8
CEPH* 200.96 a ± 63.69 50.38 a ± 17.92 25.12a ± 7.92 6.28a ± 1.99
MIC range* 128 – 256 32 - 64 16 - 32 4-8
CET † 64 16 8 2
CET* 67.52 a ± 30.48 27.09 a ± 16.94 8.44a ± 3.81 2.11a ± 0.95
MIC range* 32 – 128 16 - 64 4 - 16 1-4
IMP † 32 8 4 1
IMP* 130.88 a ± 84.02 32.72 a ± 16.15 19.88a ± 10.51 4.97a ± 2.63
MIC range* 32 – 256 8 - 64 4 - 32 1-8
ME † 64 16 8 2
ME* 135.68 a ± 54.03 33.92 a ± 13.51 16.96a ± 6.75 4.24a ± 1.69
MIC range* 64 – 256 16 - 64 8 - 32 2-8
  1. MIC of M & R is same.
  2. a= Average value.
  3. *against MRSA clinical isolates (n = 100).
  4. † against S. aureus (ATCC 43300).