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Table 5 g-score, z-score and p-value of the most relevant networks

From: In-silico prediction of drug targets, biological activities, signal pathways and regulating networks of dioscin based on bioinformatics

No

Process

Size

Target

p-value

z-score

g-score

Human

1

mRNA metabolic process (19.5%),

50

16

4.35e-39

80.59

93.09

RNA metabolic process (29.3%),

response to chemical stimulus (41.5%)

2

cell division (40.0%),

50

9

1.72e-21

55.79

55.79

mitosis (35.0%),

nuclear division(35.0%)

3

glycogen metabolic process (23.1%),

50

9

2.39e-21

54.90

54.90

cellular glucan metabolic process (23.1%),

glucan metabolic process (23.1%)

4

intracellular signaling cascade (51.3%),

50

11

2.32e-22

50.84

52.09

signal transduction (71.8%),

biological regulation (97.4%)

5

DNA metabolic process (40.5%),

50

9

1.15e-19

45.25

51.50

cellular response to DNA damage stimulus (31.0%),

response to DNA damage stimulus (31.0%)

Rat

1

peptidyl-cysteine S-nitrosylation (100.0%),

7

1

2.54e-04

62.68

62.68

drug catabolic process (100.0%),

exogenous drug catabolic process (100.0%)

2

regulation of metal ion transport (26.5%),

50

3

1.78e-08

39.59

39.59

regulation of ion transport (26.5%),

negative regulation of potassium ion transport (14.7%)

3

No processes found

4

0

1.00e + 00

0.00

0.00

Mouse

1

N-acetylglucosamine biosynthetic process (100.0%),

3

1

1.82e-04

74.17

74.17

UDP-N-acetylglucosamine biosynthetic process (100.0%),

glucosamine biosynthetic process (100.0%)

2

positive regulation of immune system process (44.8%),

50

5

1.42e-14

64.51

65.76

regulation of immune system process (51.7%),

regulation of response to stimulus (51.7%)

3

positive regulation of Schwann cell differentiation (50.0%),

16

1

5.45e-04

42.81

42.81

regulation of Schwann cell differentiation (50.0%),

response to cobalamin (50.0%)

4

response to other organism (100.0%),

5

1

9.08e-04

33.15

33.15

response to biotic stimulus (100.0%),

5

transepithelial chloride transport (33.3%),

9

1

1.09e-03

30.26

30.26

transepithelial transport (33.3%),

somatic hypermutation of immunoglobulin genes (33.3%)