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Table 4 Ten GeneGo process networks and Go processes with lower p-values

From: In-silico prediction of drug targets, biological activities, signal pathways and regulating networks of dioscin based on bioinformatics

GeneGo process network
  Network Objects Name p-value
Human 51 Development_Hemopoiesis, Erythropoietin pathway 0.000003178
Inflammation_Complement system 0.00002487
Cell cycle_G2-M 0.00004606
Signal transduction_WNT signaling 0.0001901
Signal Transduction_TGF-beta, GDF and Activin signaling 0.0007943
Cell cycle_G1-S 0.001089
Cell cycle_Meiosis 0.00169
Cell cycle_G1-S Growth factor regulation 0.00215
Muscle contraction_Nitric oxide signaling in the cardiovascular system 0.00228
Protein folding_Folding in normal condition 0.002583
Rat 7 Neurophysiological process_Transmission of nerve impulse 0.0005214
Signal Transduction_TGF-beta, GDF and Activin signaling 0.006777
Reproduction_GnRH signaling pathway 0.008233
Development_Neurogenesis: Synaptogenesis 0.009411
Cell adhesion_Synaptic contact 0.009819
Reproduction_Gonadotropins regulation 0.01165
Neurophysiological process_Taste signaling 0.02996
Cell cycle_G0-G1 0.05999
Neurophysiological process_Circadian rhythm 0.0641
Neurophysiological process_Long-term potentiation 0.06901
Mouse 11 Immune_Antigen presentation 0.0002078
Immune_Phagosome in antigen presentation 0.0004253
Immune_Innate immune response to RNA viral infection 0.001665
Inflammation_NK cell cytotoxicity 0.00532
Muscle contraction_Relaxin signaling 0.05991
Transport_Iron transport 0.06608
Immune_Th17-derived cytokines 0.06881
Inflammation_IFN-gamma signaling 0.07697
Inflammation_Interferon signaling 0.07697
Muscle contraction_Nitric oxide signaling in the cardiovascular system 0.08035
Go processes
  Network Objects Name pValue
Human 51 DNA replication 9.331E-09
protein localization in nucleus 6.994E-08
mRNA transport 1.706E-07
protein amino acid farnesylation 1.928E-07
positive regulation of biological process 2.181E-07
establishment of RNA localization 2.994E-07
nucleic acid transport 2.994E-07
RNA transport 2.994E-07
RNA localization 0.000000357
protein farnesylation 3.848E-07
Rat 7 protein amino acid farnesylation 4.46E-10
protein farnesylation 8.918E-10
positive regulation of nitric-oxide synthase 2 biosynthetic process 1.56E-09
regulation of nitric-oxide synthase 2 biosynthetic process 2.496E-09
protein amino acid prenylation 9.799E-09
protein prenylation 1.274E-08
regulation of sensory perception of pain 1.455E-07
regulation of sensory perception 1.455E-07
synaptic transmission 3.092E-07
transmission of nerve impulse 6.724E-07
Mouse 11 antigen processing and presentation of exogenous peptide antigen 4.316E-11
antigen processing and presentation of exogenous antigen 9.457E-11
antigen processing and presentation of peptide antigen 2.176E-10
antigen processing and presentation 4.237E-09
regulation of immune response 1.693E-08
positive regulation of leukocyte mediated cytotoxicity 1.706E-08
positive regulation of cell killing 2.148E-08
positive regulation of immune system process 2.238E-08
regulation of leukocyte mediated cytotoxicity 4.251E-08
regulation of cell killing 5.109E-08