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Table 4 Ten GeneGo process networks and Go processes with lower p-values

From: In-silico prediction of drug targets, biological activities, signal pathways and regulating networks of dioscin based on bioinformatics

GeneGo process network

 

Network Objects

Name

p-value

Human

51

Development_Hemopoiesis, Erythropoietin pathway

0.000003178

Inflammation_Complement system

0.00002487

Cell cycle_G2-M

0.00004606

Signal transduction_WNT signaling

0.0001901

Signal Transduction_TGF-beta, GDF and Activin signaling

0.0007943

Cell cycle_G1-S

0.001089

Cell cycle_Meiosis

0.00169

Cell cycle_G1-S Growth factor regulation

0.00215

Muscle contraction_Nitric oxide signaling in the cardiovascular system

0.00228

Protein folding_Folding in normal condition

0.002583

Rat

7

Neurophysiological process_Transmission of nerve impulse

0.0005214

Signal Transduction_TGF-beta, GDF and Activin signaling

0.006777

Reproduction_GnRH signaling pathway

0.008233

Development_Neurogenesis: Synaptogenesis

0.009411

Cell adhesion_Synaptic contact

0.009819

Reproduction_Gonadotropins regulation

0.01165

Neurophysiological process_Taste signaling

0.02996

Cell cycle_G0-G1

0.05999

Neurophysiological process_Circadian rhythm

0.0641

Neurophysiological process_Long-term potentiation

0.06901

Mouse

11

Immune_Antigen presentation

0.0002078

Immune_Phagosome in antigen presentation

0.0004253

Immune_Innate immune response to RNA viral infection

0.001665

Inflammation_NK cell cytotoxicity

0.00532

Muscle contraction_Relaxin signaling

0.05991

Transport_Iron transport

0.06608

Immune_Th17-derived cytokines

0.06881

Inflammation_IFN-gamma signaling

0.07697

Inflammation_Interferon signaling

0.07697

Muscle contraction_Nitric oxide signaling in the cardiovascular system

0.08035

Go processes

 

Network Objects

Name

pValue

Human

51

DNA replication

9.331E-09

protein localization in nucleus

6.994E-08

mRNA transport

1.706E-07

protein amino acid farnesylation

1.928E-07

positive regulation of biological process

2.181E-07

establishment of RNA localization

2.994E-07

nucleic acid transport

2.994E-07

RNA transport

2.994E-07

RNA localization

0.000000357

protein farnesylation

3.848E-07

Rat

7

protein amino acid farnesylation

4.46E-10

protein farnesylation

8.918E-10

positive regulation of nitric-oxide synthase 2 biosynthetic process

1.56E-09

regulation of nitric-oxide synthase 2 biosynthetic process

2.496E-09

protein amino acid prenylation

9.799E-09

protein prenylation

1.274E-08

regulation of sensory perception of pain

1.455E-07

regulation of sensory perception

1.455E-07

synaptic transmission

3.092E-07

transmission of nerve impulse

6.724E-07

Mouse

11

antigen processing and presentation of exogenous peptide antigen

4.316E-11

antigen processing and presentation of exogenous antigen

9.457E-11

antigen processing and presentation of peptide antigen

2.176E-10

antigen processing and presentation

4.237E-09

regulation of immune response

1.693E-08

positive regulation of leukocyte mediated cytotoxicity

1.706E-08

positive regulation of cell killing

2.148E-08

positive regulation of immune system process

2.238E-08

regulation of leukocyte mediated cytotoxicity

4.251E-08

regulation of cell killing

5.109E-08