Skip to main content

Table 2 The target proteins of dioscin from human, rat and mouse searched in PDTD

From: In-silico prediction of drug targets, biological activities, signal pathways and regulating networks of dioscin based on bioinformatics

No PDB Uniprot_id Gene symbol Protein name Gene id Energy
Human
1 2old - - Immune system - −64.3
2 1iyh PTGD2_HUMAN PTGDS2 Glutathione-requiring prostaglandin D synthase 27306 −65.2
3 1udu PDE5A_HUMAN PDE5A cGMP-specific 3′,5′-cyclic phosphodiesterase 8654 −58
4 2ax4 PAPS2_HUMAN PAPSS2 Bifunctional 3′-phosphoadenosine 5′-phosphosulfate synthetase 2 9060 −73.8
5 1ivo EGFR_HUMAN EGFR Epidermal growth factor receptor [Precursor] 1956 −67.4
6 2a73 CO3_HUMAN C3 Complement C3 [Precursor] 718 −67.6
7 1ivo EGF_HUMAN EGF Pro-epidermal growth factor [Precursor] 1950 −67.4
8 1xbt KITH_HUMAN TK1 Thymidine kinase, cytosolic 7083 −71
9 1w4r KITH_HUMAN TK1 Thymidine kinase, cytosolic 7083 −70.2
10 1l5q PYGL_HUMAN PYGL Glycogen phosphorylase, liver form 5836 −68.8
11 1pl2 GSTA1_HUMAN GSTA1 Glutathione S-transferase A1 2938 −65.1
12 1m5o SNRPA_HUMAN SNRPA U1 small nuclear ribonucleoprotein A 6626 −74
13 1tl8 TOP1_HUMAN TOP1 DNA topoisomerase 1 7150 −55.2
14 1rr8 TOP1_HUMAN TOP1 DNA topoisomerase 1 7150 −62.1
15 1nd6 PPAP_HUMAN ACPP Prostatic acid phosphatase [Precursor] 55 −57.7
16 2c5n CCNA2_HUMAN CCNA2 Cyclin-A2 890 −72.2
17 2c6t CCNA2_HUMAN CCNA2 Cyclin-A2 890 −67.4
18 2c5x CCNA2_HUMAN CCNA2 Cyclin-A2 890 −73.8
19 1yah EST1_HUMAN CES1 Liver carboxylesterase 1 [Precursor] 1066 −68.3
20 2c5n CDK2_HUMAN CDK2 Cell division protein kinase 2 1017 −72.2
21 2c6t CDK2_HUMAN CDK2 Cell division protein kinase 2 1017 −67.4
22 2c5x CDK2_HUMAN CDK2 Cell division protein kinase 2 1017 −73.8
23 1sk6 CYAA_BACAN cya Calmodulin-sensitive adenylate cyclase [Precursor] 2820138 −63.3
24 1sk6 CYAA_BACAN cya Calmodulin-sensitive adenylate cyclase [Precursor] 3361726 −63.3
25 2a4z PK3CG_HUMAN PIK3CG Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 −61.2
26 1sa4 FNTA_HUMAN FNTA Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 2339 −63.5
27 1sa4 FNTB_HUMAN FNTB Protein farnesyltransferase subunit beta 2342 −63.5
28 1h2v NCBP2_HUMAN NCBP2 Nuclear cap-binding protein subunit 2 22916 −61.2
29 2uym KIF11_HUMAN KIF11 Kinesin-like protein KIF11 3832 −58.8
30 1ko6 NUP98_HUMAN NUP98 Nuclear pore complex protein Nup98-Nup96 [Precursor] 4928 −74.2
31 2i6a ADK_HUMAN ADK Adenosine kinase 132 −66.6
32 2fdp BACE1_HUMAN BACE1 Beta-secretase 1 [Precursor] 23621 −70.2
33 2ic5 RAC3_HUMAN RAC3 Ras-related C3 botulinum toxin substrate 3 [Precursor] 5881 −75.3
34 1sk6 CALM_HUMAN CALM1 Calmodulin 801 −63.3
35 1sk6 CALM_HUMAN CALM1 Calmodulin 808 −63.3
36 1sk6 CALM_HUMAN CALM1 Calmodulin 805 −63.3
37 1 m63 PPIA_HUMAN PPIA Peptidyl-prolyl cis-trans isomerase A 5478 −81.3
38 1 m63 PPIA_HUMAN PPIA Peptidyl-prolyl cis-trans isomerase A 653214 −81.3
39 1 m63 PPIA_HUMAN PPIA Peptidyl-prolyl cis-trans isomerase A 654188 −81.3
40 1 m63 CANB1_HUMAN PPP3R1 Calcineurin subunit B type 1 5534 −81.3
41 1y4v HBB_HUMAN HBB Hemoglobin subunit beta 3043 −79.9
42 1y4g HBB_HUMAN HBB Hemoglobin subunit beta 3043 −62.1
43 1y45 HBB_HUMAN HBB Hemoglobin subunit beta 3043 −57.1
44 1y85 HBB_HUMAN HBB Hemoglobin subunit beta 3043 −55.6
45 1rq3 HBB_HUMAN HBB Hemoglobin subunit beta 3043 −63
46 1y46 HBB_HUMAN HBB Hemoglobin subunit beta 3043 −59.4
47 1y7g HBB_HUMAN HBB Hemoglobin subunit beta 3043 −71.9
48 1y4q HBB_HUMAN HBB Hemoglobin subunit beta 3043 −73.6
49 1y4v HBA_HUMAN HBA1 Hemoglobin subunit alpha 3039 −79.9
50 1y4v HBA_HUMAN HBA1 Hemoglobin subunit alpha 3040 −79.9
51 1y4g HBA_HUMAN HBA1 Hemoglobin subunit alpha 3040 −62.1
52 1y4g HBA_HUMAN HBA1 Hemoglobin subunit alpha 3039 −62.1
53 1y45 HBA_HUMAN HBA1 Hemoglobin subunit alpha 3040 −57.1
54 1y45 HBA_HUMAN HBA1 Hemoglobin subunit alpha 3039 −57.1
55 1y85 HBA_HUMAN HBA1 Hemoglobin subunit alpha 3040 −55.6
56 1y85 HBA_HUMAN HBA1 Hemoglobin subunit alpha 3039 −55.6
57 1rq3 HBA_HUMAN HBA1 Hemoglobin subunit alpha 3040 −63
58 1rq3 HBA_HUMAN HBA1 Hemoglobin subunit alpha 3039 −63
59 1y46 HBA_HUMAN HBA1 Hemoglobin subunit alpha 3040 −59.4
60 1y46 HBA_HUMAN HBA1 Hemoglobin subunit alpha 3039 −59.4
61 1y7g HBA_HUMAN HBA1 Hemoglobin subunit alpha 3040 −71.9
62 1y7g HBA_HUMAN HBA1 Hemoglobin subunit alpha 3039 −71.9
63 1y4q HBA_HUMAN HBA1 Hemoglobin subunit alpha 3040 −73.6
64 1y4q HBA_HUMAN HBA1 Hemoglobin subunit alpha 3039 −73.6
65 1fro LGUL_HUMAN GLO1 Lactoylglutathione lyase 2739 −67.4
66 1 m63 PP2BA_HUMAN PPP3CA Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform 5530 −81.3
67 1h2v NCBP1_HUMAN NCBP1 Nuclear cap-binding protein subunit 1 4686 −61.2
68 2gk6 RENT1_HUMAN UPF1 Regulator of nonsense transcripts 1 5976 −72.9
69 2ovp FBXW7_HUMAN FBXW7 F-box/WD repeat-containing protein 7 55294 −63.5
70 2pfo DPOLL_HUMAN POLL DNA polymerase lambda 27343 −60.7
71 2 h16 ARL5A_HUMAN ARL5A ADP-ribosylation factor-like protein 5A 26225 −66.6
Rat
1 1cte CATB_RAT Ctsb Cathepsin B [Precursor] - −65.8
2 1ewk GRM1_RAT Grm1 Metabotropic glutamate receptor 1 [Precursor] 24414 −68.6
3 1zzu NOS1_RAT Nos1 Nitric oxide synthase, brain 24598 −74.3
4 1rs6 NOS1_RAT Nos1 Nitric oxide synthase, brain 24598 −76.2
5 1kzo FNTB_RAT Fntb Protein farnesyltransferase subunit beta 64511 −67.4
6 2bed FNTB_RAT Fntb Protein farnesyltransferase subunit beta 64511 −71.5
7 1kzo FNTA_RAT Fnta Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 25318 −67.4
Mouse
1 2ihm DPOLM_MOUSE Polm DNA polymerase mu 54125 −59.2
2 1f3a GSTA1_MOUSE Gsta1 Glutathione S-transferase A1 14857 −63
3 2oi9 HA1L_MOUSE H2-L H-2 class I histocompatibility antigen, L-D alpha chain [Precursor] - −62.1
4 1iea HA21_MOUSE H2-Ea H-2 class II histocompatibility antigen, E-D alpha chain [Precursor] - −66.5
5 1fng HA22_MOUSE - H-2 class II histocompatibility antigen, E-K alpha chain [Precursor] - −66.1
6 1qom NOS2_MOUSE Nos2 Nitric oxide synthase, inducible 18126 −66.2
7 2gb4 TPMT_MOUSE Tpmt Thiopurine S-methyltransferase 22017 −57.5
8 2oi9 TVA1_MOUSE - T-cell receptor alpha chain V region PHDS58 [Precursor]