The top two networks scored by MetaCore (AN network) of human (A and B), rat (C and D) and mouse (E and F). A: mRNA metabolic process, RNA metabolic process and response to chemical stimulus of human; B: cell division, mitosis and nuclear division; C: peptidyl-cysteine S-nitrosylation, drug catabolic process and exogenous drug catabolic process; D: regulation of metal ion transport, ion transport and negative regulation of potassium ion transport; E: N-acetylglucosamine biosynthetic, UDP-N-acetylglucosamine biosynthetic and glucosamine biosynthetic process; F: positive regulation of immune system, regulation of immune system and response to stimulus. Thick cyan lines indicate the fragments of canonical pathways. Upregulated genes are marked with red circles; downregulated with blue circles. The ‘checkerboard’ color indicates mixed expression for the gene between files or between multiple tags for the same gene.