Figure 3

Observation of pathological changes in the brain and spinal cord of mice under the light microscope (scale bar, 20 μm) on Day 18 PI of EAE. NC mice showed normal structures, while EAE mice had large amounts of inflammatory cell infiltration. PA- and BSYSC-treated EAE mice exhibited a small number of inflammatory cells than EAE mice. Note: ^***p <0.001 vs.NC; ^###p <0.001 vs. EAE.