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Table 2 The mean MIC values (mg/mL) and ΣFIC values (given in brackets with interactive interpretation) of crude dichloromethane:methanol and aqueous extracts used in 1:1 combinations and tested against seven bacterial diarrhoeal pathogens

From: Antimicrobial evaluation of plants used for the treatment of diarrhoea in a rural community in northern Maputaland, KwaZulu-Natal, South Africa

Plant combinations

Pathogens

B. cereus

E. faecalis

E. coli

P. vulgaris

S. typhimurium

S. flexneri

S. aureus

ΣFIC Averages

ATCC 11778

ATCC 29212

ATCC 8739

ATCC 33420

ATCC 14028

ATCC 25875

ATCC 12600

Organic

Aqueous

Organic

Aqueous

Organic

Aqueous

Organic

Aqueous

Organic

Aqueous

Organic

Aqueous

Organic

Aqueous

Organic

Aqueous

A. glabratum and K. mosambicina

0.03

12.00

6.00

8.00

NSa

16.00

0.16

4.00

0.63

4.00

0.03

16.00

0.04

8.00

0.30

1.70

(0.02 S b )

(1.88 NIc)

(1.13 NI)

(NDd NI)

(ND ANTe)

(ND NI)

(ND S)

(N.D Af)

(0.26 S)

(0.63 A)

(0.07 S)

(3.20 NI)

(0.01 S)

(1.09 NI)

A. glabratum and P. guajava

0.03

4.00

0.31

4.00

0.16

NS

0.31

2.00

0.31

8.00

0.23

8.00

0.16

2.00

0.46

2.00

(0.13 S)

(2.38 NI)

(1.27 NI)

(ND S)

(0.03 S)

(ND NI)

(ND S)

(ND S)

(0.37 S)

(1.17 NI)

(0.78 A)

(2.33 NI)

(0.17 S)

(2.14 NI)

B. transvaalensis and P. guajava

0.02

8.00

0.16

NS

0.16

16.00

0.23

2.00

0.31

2.00

0.02

8.00

0.31

4.00

0.39

2.33

(0.10 S)

(ND NI)

(1.23 NI)

(ND NI)

(0.06 S)

(ND NI)

(0.11 S)

(ND S)

(0.48 S)

(ND S)

(0.05 S)

(2.33 NI)

(0.62 A)

(ND NI)

B. transvaalensis and S. birrea

0.03

8.00

0.63

8.00

0.63

NS

0.16

3.00

0.31

12.00

0.02

1.50

0.48

3.00

0.88

0.57

(0.16 S)

(ND S)

(3.32 NI)

(ND S)

(0.34 S)

(ND NI)

(0.13 S)

(ND A)

(1.10 NI)

(ND NI)

(0.04 S)

(0.57 A)

(1.11 NI)

(ND NI)

Acetone control

16.00

16.00

NS

NS

NS

NS

13.30

13.30

NS

NS

8.00

8.00

NS

NS

NAg

Ciprofloxacin control (μg/mL)

0.50

0.25

0.02

0.40

0.20

0.05

0.80

  1. NSa = Not susceptible at highest concentration tested; Sb = Synergy; NIc = Non interaction; NDd = Not determined as no end point MIC is available for one or both plants. Tentative interaction is given based on MIC values. ANTe = antagonism; Af = Additive. NAg = Not applicable; Noteworthy values depicted in bold font.