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Table 2 The mean MIC values (mg/mL) and ΣFIC values (given in brackets with interactive interpretation) of crude dichloromethane:methanol and aqueous extracts used in 1:1 combinations and tested against seven bacterial diarrhoeal pathogens

From: Antimicrobial evaluation of plants used for the treatment of diarrhoea in a rural community in northern Maputaland, KwaZulu-Natal, South Africa

Plant combinations Pathogens
B. cereus E. faecalis E. coli P. vulgaris S. typhimurium S. flexneri S. aureus ΣFIC Averages
ATCC 11778 ATCC 29212 ATCC 8739 ATCC 33420 ATCC 14028 ATCC 25875 ATCC 12600
Organic Aqueous Organic Aqueous Organic Aqueous Organic Aqueous Organic Aqueous Organic Aqueous Organic Aqueous Organic Aqueous
A. glabratum and K. mosambicina 0.03 12.00 6.00 8.00 NSa 16.00 0.16 4.00 0.63 4.00 0.03 16.00 0.04 8.00 0.30 1.70
(0.02 S b ) (1.88 NIc) (1.13 NI) (NDd NI) (ND ANTe) (ND NI) (ND S) (N.D Af) (0.26 S) (0.63 A) (0.07 S) (3.20 NI) (0.01 S) (1.09 NI)
A. glabratum and P. guajava 0.03 4.00 0.31 4.00 0.16 NS 0.31 2.00 0.31 8.00 0.23 8.00 0.16 2.00 0.46 2.00
(0.13 S) (2.38 NI) (1.27 NI) (ND S) (0.03 S) (ND NI) (ND S) (ND S) (0.37 S) (1.17 NI) (0.78 A) (2.33 NI) (0.17 S) (2.14 NI)
B. transvaalensis and P. guajava 0.02 8.00 0.16 NS 0.16 16.00 0.23 2.00 0.31 2.00 0.02 8.00 0.31 4.00 0.39 2.33
(0.10 S) (ND NI) (1.23 NI) (ND NI) (0.06 S) (ND NI) (0.11 S) (ND S) (0.48 S) (ND S) (0.05 S) (2.33 NI) (0.62 A) (ND NI)
B. transvaalensis and S. birrea 0.03 8.00 0.63 8.00 0.63 NS 0.16 3.00 0.31 12.00 0.02 1.50 0.48 3.00 0.88 0.57
(0.16 S) (ND S) (3.32 NI) (ND S) (0.34 S) (ND NI) (0.13 S) (ND A) (1.10 NI) (ND NI) (0.04 S) (0.57 A) (1.11 NI) (ND NI)
Acetone control 16.00 16.00 NS NS NS NS 13.30 13.30 NS NS 8.00 8.00 NS NS NAg
Ciprofloxacin control (μg/mL) 0.50 0.25 0.02 0.40 0.20 0.05 0.80
  1. NSa = Not susceptible at highest concentration tested; Sb = Synergy; NIc = Non interaction; NDd = Not determined as no end point MIC is available for one or both plants. Tentative interaction is given based on MIC values. ANTe = antagonism; Af = Additive. NAg = Not applicable; Noteworthy values depicted in bold font.