LLDT-8 up-regulated OPG expression and increased the ratio of OPG/RANKL on CD3+T leukomonocyte in peripheral blood of RA patients. PBMCs were isolated from peripheral blood of RA patients and treated with various concentrations of LLDT-8 (0, 25 nM and 50 nM, respectively) for 24 hours, then stained and detected by flow cytometry. (A) The psuedocolor plots of OPG, RANK and RANKL. (B) The rate of OPG expression on CD3+ T leukomonocyte in the three groups. (C) The ratio of OPG to RANKL on CD3+ T leukomonocyte in the three groups. *p < 0.05 compared to the control group (0 nM).