Antinociceptive effect of methanol extract of leaves of Persicaria hydropiper in mice

Table 7 Effect of leaf extract of P. hydropiper extract on involvement of cyclic guanosine monophosphate (cGMP) pathway

Treatment	Dose (mg/kg)	Number of writhing	Inhibition (%)
Control	0.1 ml/mouse	59.1 ± 1.86	-
Methylene Blue (MB)	20	52.8 ± 3.15	10.66
MEPH + MB	25 + 20	6.9 ± 0.73*	88.32
MEPH + MB	50 + 20	5.8 ± 1.88*	90.19
MEPH + MB	75 + 20	5.3 ± 3.85*	91.03

Each value is presented as the Mean ± SEM (n = 5). MEPH = Methanolic extract of P. hydropiper leaves.
*p < 0.001 compared with the control group (Dunnett’s test).

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