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Table 2 Effect of leaf extract of P. hydropiper extract in tail immersion test

From: Antinociceptive effect of methanol extract of leaves of Persicaria hydropiper in mice

Treatment Dose (mg/kg) Latency period (in sec) (% MPE)
Pretreatment 30 min 60 min 90 min 120 min
Control 0.1 ml/mouse 1.93 ± 0.12 2.01 ± 0.13 2.27 ± 0.12 2.31 ± 0.20 2.51 ± 0.17
Morphine 5 2.48 ± 0.28 3.93 ± 0.19*(8.27) 6.13 ± 0.32*(13.69) 9.34 ± 0.11*(23.14) 4.35 ± 0.22(31.88)
MEPH 25 2.63 ± 0.10 5.25 ± 0.09*(15.07) 5.55 ± 0.22* (2.03) 6.22 ± 0.23*(4.63) 4.25 ± 0.10(-14.29)
MEPH 50 2.77 ± 0.33 5.67 ± 0.19*(16.83) 5.87 ± 0.17*(1.39) 6.49 ± 0.21(4.38) 5.36 ± 0.42*(-8.43)
MEPH 75 2.57 ± 0.29 3.31 ± 0.55*(4.24) 3.49 ± 0.23*(1.08) 4.23 ± 0.30*(4.48) 5.08 ± 0.34*(5.38)
NLX 2 4.98 ± 0.09 3.53 ± 0.13 3.68 ± 0.24 3.27 ± 0.18 3.16 ± 0.34
NLX + Control 2 + 0.1 ml/mouse 2.96 ± 0.15 3.14 ± 0.13 3.71 ± 0.24 4.16 ± 0.18 4.11 ± 0.34
NLX+ Morphine 2 + 5 2.59 ± 0.08 2.66 ± 0.21a(0.40) 2.72 ± 0.18a(0.34) 2.96 ± 0.20a(1.39) 2.73 ± 0.18a(1.34)
NLX + MEPH 2 + 25 2.35 ± 0.36 2.48 ± 0.17b(0.73) 3.31 ± 0.14(4.73) 3.32 ± 0.25b(0.05) 3.39 ± 0.16b(0.42)
NLX + MEPH 2 + 50 2.43 ± 0.14 2.36 ± 0.19c(-0.39) 2.24 ± 0.34c(-0.68) 3.19 ± 0.16c(5.34) 2.89 ± 0.21c(-1.78)
NLX+ MEPH 2 + 75 1.98 ± 0.10 1.95 ± 0.21d(-0.16) 1.98 ± 0.17d(0.16) 2.65 ± 0.24d(3.71) 3.01 ± 0.21d(3.63)
  1. Each value is presented as the mean ± SEM (n = 5). MEPH = Methanolic extract of. P. hydropiper leaves; NLX = Naloxone.
  2. *p < 0.001 compared with the control group (Dunnett’s test).
  3. ap < 0.001 compared with the morphine group (Bonferroni’s test).
  4. bp < 0.05 compared with the MEPH 25 group (Bonferroni’s test).
  5. cp < 0.01 compared with the MEPH 50 group (Bonferroni’s test).
  6. dp < 0.01 compared with the MEPH 75 group (Bonferroni’s test).