Table 2 Effect of leaf extract of P. hydropiper extract in tail immersion test

Control

0.1 ml/mouse

1.93 ± 0.12

2.01 ± 0.13

2.27 ± 0.12

2.31 ± 0.20

2.51 ± 0.17

Morphine

5

2.48 ± 0.28

3.93 ± 0.19*(8.27)

6.13 ± 0.32*(13.69)

9.34 ± 0.11*(23.14)

4.35 ± 0.22(31.88)

MEPH

25

2.63 ± 0.10

5.25 ± 0.09*(15.07)

5.55 ± 0.22* (2.03)

6.22 ± 0.23*(4.63)

4.25 ± 0.10(-14.29)

MEPH

50

2.77 ± 0.33

5.67 ± 0.19*(16.83)

5.87 ± 0.17*(1.39)

6.49 ± 0.21(4.38)

5.36 ± 0.42*(-8.43)

MEPH

75

2.57 ± 0.29

3.31 ± 0.55*(4.24)

3.49 ± 0.23*(1.08)

4.23 ± 0.30*(4.48)

5.08 ± 0.34*(5.38)

NLX

2

4.98 ± 0.09

3.53 ± 0.13

3.68 ± 0.24

3.27 ± 0.18

3.16 ± 0.34

NLX + Control

2 + 0.1 ml/mouse

2.96 ± 0.15

3.14 ± 0.13

3.71 ± 0.24

4.16 ± 0.18

4.11 ± 0.34

NLX+ Morphine

2 + 5

2.59 ± 0.08

2.66 ± 0.21^a(0.40)

2.72 ± 0.18^a(0.34)

2.96 ± 0.20^a(1.39)

2.73 ± 0.18^a(1.34)

NLX + MEPH

2 + 25

2.35 ± 0.36

2.48 ± 0.17^b(0.73)

3.31 ± 0.14(4.73)

3.32 ± 0.25^b(0.05)

3.39 ± 0.16^b(0.42)

NLX + MEPH

2 + 50

2.43 ± 0.14

2.36 ± 0.19^c(-0.39)

2.24 ± 0.34^c(-0.68)

3.19 ± 0.16^c(5.34)

2.89 ± 0.21^c(-1.78)

NLX+ MEPH

2 + 75

1.98 ± 0.10

1.95 ± 0.21^d(-0.16)

1.98 ± 0.17^d(0.16)

2.65 ± 0.24^d(3.71)

3.01 ± 0.21^d(3.63)