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Table 2 Effect of ZO-ActFr (50 mg/kg) administered 30 minutes before saline administration, on the basal level of neurotransmitters and their metabolites (ng/mg tissue wet weight) in the brain areas and intestine in pigeons at t = 3 hr (n = 6–8)

From: Anti-emetic mechanisms of zingiber officinale against cisplatin induced emesis in the pigeon; behavioral and neurochemical correlates

Treatment

NA

DOPAC

DA

5HIAA

HVA

5HT

Area postrema

Saline

0.610 ± 0.014

0.382 ± 0.111

0.590 ± 0.146

0.158 ± 0.036

0.913 ± 0.095

0.062 ± 0.034

MCP 30 mg

0.023 ± 0.005

0.017 ± 0.006

0.025 ± 0.012

0.005 ± 0.001*

0.121 ± 0.063*

0.023 ± 0.001

ZO-ActFr 50 mg

0.372 ± 0.036

0.122 ± 0.047

0.191 ± 0.037

0.039 ± 0.006

0.874 ± 0.204

0.045 ± 0.008

Brain stem

Saline

0.094 ± 0.022

0.060 ± 0.020

0.175 ± 0.078

0.060 ± 0.021

0.060 ± 0.016

0.010 ± 0.003

MCP 30 mg

0.119 ± 0.033

0.027 ± 0.006

0.044 ± 0.012

0.007 ± 0.001***

0.066 ± 0.031

0.019 ± 0.002

ZO-ActFr 50 mg

0.056 ± 0.055

0.128 ± 0.127

0.082 ± 0.054

0.011 ± 0.001*

0.088 ± 0.021

0.020 ± 0.001

Intestine

Saline

0.194 ± 0.059

0.067 ± 0.020

0.090 ± 0.064

0.076 ± 0.058

0.056 ± 0.025

0.049 ± 0.016

MCP 30 mg

0.138 ± 0.039

0.054 ± 0.025

0.059 ± 0.018

0.097 ± 0.022

0.198 ± 0.102

0.062 ± 0.013

ZO-ActFr 50 mg

0.334 ± 0.131

0.037 ± 0.028

0.356 ± 0.113

0.050 ± 0.008

0.231 ± 0.110

0.103 ± 0.015

  1. Standard MCP is also shown.
  2. Values significantly different compared to basal level (saline) are indicated as *p < 0.05, ***p < 0.001 (ANOVA followed by Tukey post hoc analysis).