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Table 4 Biochemical parameters of male and female rats administered with Derris reticulata extract for 42 days

From: Antioxidant, α-glucosidase inhibitory activity and sub-chronic toxicity of Derris reticulata extract: its antidiabetic potential

Parameters

Control

Treatment

250 mg/kg

500 mg/kg

1000 mg/kg

2000 mg/kg

Male

     

Glucose (mg/dl)

125.8 ± 10.4

114.3 ± 10.7

135.8 ± 5.1

114.0 ± 2.0

118.5 ± 4.3

Total cholesterol (mg/dl)

61.50 ± 2.60

52.75 ± 3.50

61.50 ± 4.52

44.50 ± 2.84

50.75 ± 5.82

Triglyceride (mg/dl)

80.75 ± 18.44

85.50 ± 6.61

81.75 ± 13.83

76.75 ± 6.16

93.75 ± 23.02

Creatinine (mg/dl)

0.78 ± 0.09

0.65 ± 0.03

0.69 ± 0.04

0.68 ± 0.01

0.67 ± 0.04

AST (U/l)

96.25 ± 7.39

96.00 ± 6.49

99.00 ± 9.46

95.00 ± 10.98

98.00 ± 8.37

ALT (U/l)

32.75 ± 4.27

28.25 ± 3.64

33.25 ± 2.93

25.50 ± 2.72

29.25 ± 3.09

Female

     

Glucose (mg/dl)

101.0 ± 8.2

91.00 ± 2.1

104.5 ± 7.0

101.8 ± 7.0

83.75 ± 4.4

Total cholesterol (mg/dl)

53.00 ± 2.80

45.50 ± 3.20

45.75 ± 4.64

44.25 ± 1.49

42.25 ± 5.47

Triglyceride (mg/dl)

40.50 ± 10.21

47.25 ± 3.50

52.25 ± 14.63

35.75 ± 2.87

47.75 ± 7.12

Creatinine (mg/dl)

0.74 ± 0.06

0.83 ± 0.06

0.73 ± 0.04

0.74 ± 0.07

0.76 ± 0.02

AST (U/l)

93.75 ± 6.21

86.00 ± 5.87

88.00 ± 7.36

75.00 ± 5.45

86.00 ± 4.06

ALT (U/l)

24.25 ± 2.50

35.25 ± 13.33

23.75 ± 1.55

19.25 ± 0.48

23.00 ± 1.47

  1. Values are expressed as mean ± S.E.M. (n = 4/group).
  2. There was no significant difference among control and treatment groups (p > 0.05).