Changes in coagulation in heatstroke mice. Mice pretreated with 4 ml/kg of XBJ (HSXBJ group) or 0.9% saline (HS group) were subjected to heat insults. Coagulation was evaluated by measuring (A) TT, (B) PT, (C) APTT, (D) INR, and (E) fibrinogen. *P < 0.05, **P < 0.001, vs Sham; #P < 0.05, ##P <0.001, vs HS group. TT, thrombin time; PT, prothrombin time; APTT, activated partial thromboplastin time; INR, international normalized ratio.