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Table 2 Frequency of chromosomal aberrations in bone marrow cells from mice treated by SAA

From: Mutagenicity of Chinese traditional medicine Semen Armeniacae amarum by two modified Ames tests

Treatment

Chromosomal aberration

Aberrations per 100 cells

 

G'

G"

B'

B"

Total

 

Control (water)

14

0

5

0

19

1.9 ± 0.88

CTX (40 mg kg-1)

47

4

258

2

311

31.1 ± 1.56**

SAA (g kg-1)

      

   2.5

12

0

7

0

19

1.91 ± 1.37

   5.0

14

1

8

0

23

2.3 ± 0.67

   10.0#

10

0

7

0

17

1.7 ± 0.95

  1. The mice were sacrificed 6 h after treatment with colchicine. One hundred cells were analyzed per animal for a total of 1000 cells per treatment. CTX = cyclophosphamide; G' = chromatid gap; G" = chromosome gap; B' = chromatid break; B" = chromosome break.
  2. **Significantly different vs the negative control (P < 0.01, χ2 test).
  3. # The highest SAA dose was nearly the maximum tolerated dose.
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