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Table 1 Mutagenicity of SAA obtained by the modified Ames test with TA100*

From: Mutagenicity of Chinese traditional medicine Semen Armeniacae amarum by two modified Ames tests

SAA concentration (mg mL-1)

Free (total) histidine in SAA (μg g-1)#

his +

his +

C/A

C/B

C/b

1000

35.4 (233.4)

-

-

-

-

-

125

7.65 (15.90)

921B(1218b)

1529C

14.42

1.66

1.26

62.5

3.78 (7.95)

658B(965b)

843C

7.95

1.28

0.87

31.25

1.89 (3.875)

526B(673b)

796C

7.51

1.51

1.18

15.625

0.945 (1.94)

461B(494b)

704C

6.64

1.53

1.43

7.812

0.47 (0.097)

428B(477b)

532C

5.02

1.24

1.12

3.906

0.24 (0.049)

412B(406b)

271C

2.56

0.66

0.67

0

0

 

106A

   

Positive control

  

795

   
  1. * TA100 positive control was 0.5 μg mL-1 NaN3.
  2. # Histidine concentration was measured using BIOCHROM 30.
  3. A: number of his +revertants per plate in the standard negative control. B: Number of his + revertants per plate in the modified negative control (I), test medium contained the same amount of histidine as the free histidine in SAA. b: Number of his + revertants per plate in the modified negative control (II), test medium contained the same amount of histidine as the total histidine in SAA. C: Number of his + revertants per plate in the SAA treatment group.