Healing Potential of Picrorhiza kurroa (Scrofulariaceae) rhizomes against indomethacin-induced gastric ulceration: a mechanistic exploration.

Table 2 The effect of PK and Omez on the levels of TBARS, protein carbonyls, non-protein thiol, and mucin in the ulcerated gastric tissue of mice^a on day three of ulceration

Parameters	Group I normal control	Group III 3^rd day ulcerated control	Group V PK-treated	Group VI Omez-treated
TBARS (nmoles/mg protein)	1.02 ± 0.06	1.53 ± 0.06^c	1.03 ± 0.09^d	1.08 ± 0.05^d
Protein carbonyls (nmoles/mg protein)	1.18 ± 0.07	2.61 ± 0.17^c	1.62 ± 0.10^f	1.59 ± 0.09^f
NP-TSH (nmoles/mg tissue)	2.06 ± 0.09	1.73 ± 0.09	2.06 ± 0.14^d	2.05 ± 0.1^d
mucin (μg/g tissue)	343.30 ± 16.91	213.29 ± 17.91^b	303.34 ± 17.4^e	295.06 ± 15.62^e

^aStomach ulceration in mice was induced by oral administration of indomethacin (18 mg/kg). PK (20 mg/kg/day × 3 days) and Omez (3 mg/kg/day × 3 days) were used as the test samples. The assays were carried out on day three of ulceration, 4 h after the last dose of the drug. The values are mean ± SEM (n = 15). ^b P < 0.05, ^c P 0.001 compared to normal mice, ^d P < 0.05, ^e P < 0.01, ^f P < 0.001 compared to the group III mice.

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