Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors

Table 2 Effect of flumazenil on the anticonvulsant activity of Pasipay and diazepam in PTZ-induced convulsion in mice

Treatment (dose)	Onset (sec)	Duration (sec)	Mortality protection (%)
Normal saline (10 ml/kg)	51.83 ± 64	12 ± 1.80	0
Flumazenil (2 mg/kg)	44.71 ± 1.44	8.25	85
Diazepam (0.5 mg/kg)	485.5 ± 74.97***	3.5 ± 2.21*	90
Diazepam+ Flumazenil	152.5 ± 28.9	12.25 ± 3.42	70
Pasipay (0.4 mg/kg)	600 ± 0***	0 ± 0***	100
Pasipay+ Flumazenil	184.33 ± 29.1	11 ± 1.52	50

Normal saline, diazepam and Pasipay were administered (i.p.) 30 min before the PTZ (90 mg/kg, i.p.); Flumazenil was administered 35 min before the injection of PTZ (90 mg/kg, i.p.); Values are the mean ± S.E.M. for 10 mice; *p < 0.05; ***p < 0.001, compared with saline group, Tukey-Kramer test.

ISSN: 2662-7671