|
Treatment (dose)
|
Onset (sec)
|
Duration (sec)
|
Mortality protection (%)
|
|---|
|
Normal saline (10 ml/kg)
|
51.83 ± 64
|
12 ± 1.80
|
0
|
|
Flumazenil (2 mg/kg)
|
44.71 ± 1.44
|
8.25
|
85
|
|
Diazepam (0.5 mg/kg)
|
485.5 ± 74.97***
|
3.5 ± 2.21*
|
90
|
|
Diazepam+ Flumazenil
|
152.5 ± 28.9
|
12.25 ± 3.42
|
70
|
|
Pasipay (0.4 mg/kg)
|
600 ± 0***
|
0 ± 0***
|
100
|
|
Pasipay+ Flumazenil
|
184.33 ± 29.1
|
11 ± 1.52
|
50
|
- Normal saline, diazepam and Pasipay were administered (i.p.) 30 min before the PTZ (90 mg/kg, i.p.); Flumazenil was administered 35 min before the injection of PTZ (90 mg/kg, i.p.); Values are the mean ± S.E.M. for 10 mice; *p < 0.05; ***p < 0.001, compared with saline group, Tukey-Kramer test.
