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Table 2 Effect of flumazenil on the anticonvulsant activity of Pasipay and diazepam in PTZ-induced convulsion in mice

From: Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors

Treatment (dose) Onset (sec) Duration (sec) Mortality protection (%)
Normal saline (10 ml/kg) 51.83 ± 64 12 ± 1.80 0
Flumazenil (2 mg/kg) 44.71 ± 1.44 8.25 85
Diazepam (0.5 mg/kg) 485.5 ± 74.97*** 3.5 ± 2.21* 90
Diazepam+ Flumazenil 152.5 ± 28.9 12.25 ± 3.42 70
Pasipay (0.4 mg/kg) 600 ± 0*** 0 ± 0*** 100
Pasipay+ Flumazenil 184.33 ± 29.1 11 ± 1.52 50
  1. Normal saline, diazepam and Pasipay were administered (i.p.) 30 min before the PTZ (90 mg/kg, i.p.); Flumazenil was administered 35 min before the injection of PTZ (90 mg/kg, i.p.); Values are the mean ± S.E.M. for 10 mice; *p < 0.05; ***p < 0.001, compared with saline group, Tukey-Kramer test.