Figure 3
HPV 16 mediates the proliferation-inhibitory effects of PAC on OSCC. PAC dosage of 50 μg/mL was the GIMAX for both CAL 27 and CAL 27-TF16 cells. PAC doses greater than 20 μg/mL resulted in a net loss of cells in the CAL 27 assays, but was modulated by the presence of HPV 16 at dosages above 40 μg/mL in the CAL 27-TF16 assays.