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Table 2 Effect of Perna and DMG on established CIA in mice

From: Immunomodulation of murine collagen-induced arthritis by N, N-dimethylglycine and a preparation of Perna canaliculus

Group N Treatment (mg/kg/day) Initial Arthritic Score Final Arthritic Score
Control 15 N/A 2.0 ± 0.13 2.63 ± 0.55
Perna 12 100 2.2 ± 0.2 1.42 ± 0.24 a
DMG 12 100 2.1 ± 0.17 2.71 ± 0.41
  1. CIA was induced and mice were treated as indicated. Initial and final arthritic scores were determined by averaging individual daily scores within a group (mean ± s.e.m.). The arthritic score was graded from 0–3: 0, no pathology; 1, swelling in one limb; 2, moderate swelling in multiple limbs with joint locking; and 3, pronounced swelling in all four limbs with joint locking. To determine statistical significance, treatment groups were compared to the control group and analyzed by the Kruskal-Wallis test. aindicates p < 0.05 compared to controls.