From: Treating asthma with omega-3 fatty acids: where is the evidence? A systematic review
 | Study groups1 |  |  | |
---|---|---|---|---|
Author, Year, Location: Length & Design | Group 1 (n)/Group 4 (n) | Group 2 (n)/Group 3 (n) | Jadad Total Quality/Allocation Concealment (Internal Validity) | Applicability |
ADULTS | ||||
Arm, 1988[18] England: 10-wk parallel RCT | 3.2 g/d EPA + 2.2 g/d DHA (n = NR) | Olive oil placebo (dose: NR) (n = NR) | 4/Unclear | III |
Emelyanov, 2002[23] Russia: 8-wk parallel RCT | 200 mg/d EPA/DHA + 400 mg/d olive oil (n = 23) | 600 mg/d olive oil placebo (n = 23) | 5/Unclear | III |
Kirsch, 1988[22] USA: 8-wk parallel RCT | 4.0 g/d EPA ethyl ester (+ trace DHA) (n = 6) | 0.1 g/d EPA ethyl ester (+ trace DHA) (n = 6) | 3/Unclear | I |
McDonald, 1991[15] Australia: 10-wk crossover RCT | 2.7 g/d EPA + 1.8 g/d DHA (n = 15) | 15 g/d olive oil placebo (n = 15) | 3/Unclear | III |
Okamoto, 2000[19] Japan: 4-wk RCT | 10–20 g/d perilla seed oil (ALA: NR) (n = 7) | 10–20 g/d corn oil (n = 7) | 2/Unclear | III |
Stenius-Aarniala, 1989[21] Finland: 10-wk crossover RCT | 20 mL/d fish oil (EPA+DHA: NR) (n = 36) | 20 mL/d olive oil (n = 36)/20 mL/d evening primrose oil (n-6) (n = 36) | 2/Unclear | III |
Thien, 1993[20] England: 26-wk parallel RCT | 3.2 g/d EPA + 2.2 g/d DHA (n = NR) | Olive oil placebo (dose: NR) (n = NR) | 4/Unclear | III |
CHILDREN | ||||
Hodge, 1998[17] Australia: 26-wk parallel RCT | 0.72 g/d EPA 0.48 g/d DHA + ALA (dose: NR) via canola diet (n = NR) | n-6: 1.8 g/d safflower oil + 1.8 g/d palm oil + 0.4 g/d olive oil + sunflower diet (dose: NR) (n = NR) | 3/Unclear | III |
Nagakura, 2000[16] Japan: 10-mo parallel RCT | 17.0–26.8 mg/kg/d EPA; 7.3–11.5 mg/kg/d DHA (300 mg/d fish oil) (n = 15) | 300 mg/d olive oil placebo (n = 15) | 4/Unclear | III |
AGE NOT REPORTED | ||||
Dry, 1991[24] France: 9-mo parallel RCT | 1.0 g/d EPA+DHA (n = NR) | "Placebo" (type & dose: NR) (n = NR) | 2/Unclear | X |