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Table 5 Mean changes of VAS that assessed pain and stiffness, Lequesne's functional index and time for climbing up 10 steps in intent-to-treat patients (n = 100/group).

From: Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial [ISRCTN70292892]

Variable

Treatment Group

Week 0–1

Week 0–2

Week 0–3

Week 0–4

VAS that assessed pain (mm)

   Walking pain

DJW

-16.96 (1.68)

-26.82 (1.97)

-36.54 (2.31)

-46.48 (2.41)

 

Diclofenac

-20.70† (1.60)

-29.80 (1.95)

-40.58 (2.26)

-50.47 (2.38)

   Standing pain

DJW

-12.61 (1.80)

-20.81 (2.23)

-28.13 (2.28)

-35.53 (2.34)

 

Diclofenac

-15.93† (1.33)

-25.33 (1.83)

-32.41 (2.04)

-40.66 (2.25)

   Pain during climbing up and down stairs

DJW

-16.78 (1.95)

-26.68 (2.30)

-34.93 (2.26)

-44.67 (2.22)

 

Diclofenac

-18.79 (1.40)

-30.08 (1.91)

-38.11 (2.04)

-46.86 (2.35)

   Night pain

DJW

-16.71 (2.32)

-26.60 (2.25)

-34.47 (2.42)

-40.88 (2.59)

 

Diclofenac

-19.52 (1.98)

-27.58 (2.30)

-33.43 (2.51)

-39.80 (2.81)

   Resting pain

DJW

-11.23 (1.24)

-18.52 (1.46)

-25.84 (1.86)

-31.06 (2.02)

 

Diclofenac

-14.28 (1.34)

-20.86 (1.91)

-25.82 (2.07)

-30.54 (2.38)

   Total paina

DJW

-74.27 (6.53)

-119.42 (7.42)

-159.90 (7.85)

-198.61 (8.51)

 

Diclofenac

-89.21 (5.25)

-133.64 (7.02)

-170.34 (7.65)

-208.33 (9.03)

   Pain during the most painful knee movement

DJW

-18.94 (2.11)

-32.48 (2.63)

-44.56 (2.77)

-55.44 (2.67)

 

Diclofenac

-24.38 (2.10)

-37.53 (2.51)

-48.07 (2.57)

-58.33 (2.59)

VAS that assessed stiffness (mm)

   Morning stiffness

DJW

-16.93 (1.98)

-25.50 (2.24)

-33.87 (2.46)

-41.19 (2.58)

 

Diclofenac

-19.59† (1.69)

-29.80 (2.10)

-38.13 (2.47)

-45.42 (2.63)

   Stiffness after rest

DJW

-16.83 (1.97)

-29.12 (2.41)

-39.48 (2.50)

-48.91 (2.54)

 

Diclofenac

-20.74† (1.72)

-30.91 (2.07)

-42.22 (2.29)

-51.55 (2.40)

   Total stiffnessb

DJW

-33.76 (3.48)

-54.62 (4.02)

-73.35 (4.21)

-90.10 (4.27)

 

Diclofenac

-40.33† (3.05)

-60.71 (3.72)

-80.35 (4.21)

-96.97 (4.47)

Lequesne's functional index (score)

DJW

-2.60 (0.34)

-3.15 (0.32)

-4.28 (0.37)

-5.29 (0.38)

 

Diclofenac

-3.92† (0.31)

-4.16† (0.32)

-5.22 (0.36)

-6.16 (0.40)

Time for climbing up 10 steps (s)

DJW

-1.79 (0.33)

-2.02 (0.31)

-2.50 (0.32)

-2.94 (0.32)

 

Diclofenac

-2.05 (0.31)

-2.18 (0.34)

-2.71 (0.34)

-3.13 (0.33)

  1. Data represent mean (SD). aSummation of VAS that assessed walking pain, standing pain, pain during climbing up and down stairs, night pain and resting pain. bSummation of VAS that assessed morning stiffness and stiffness after rest. † p < 0.05 versus the DJW group at the same duration of treatment.