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Table 4 Mean VAS that assessed pain and stiffness, Lequesne's functional index and time for climbing up 10 steps in intent-to-treat patients (n = 100/group).

From: Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial [ISRCTN70292892]

Variable

Treatment Group

Week 0

Week 1

Week 2

Week 3

Week 4

% improvementa

VAS that assessed pain (mm)

   Walking pain

DJW

64.53 (24.92)

47.58* (25.33)

37.72* (25.00)

28.00* (23.25)

18.06* (20.76)

72.01

 

Diclofenac

64.78 (25.14)

44.08* (23.43)

34.99* (22.07)

24.21* (21.00)

14.31* (16.10)

77.91

   Standing pain

DJW

52.42 (25.87)

39.81* (26.09)

31.61* (24.89)

24.29* (22.98)

16.89* (20.59)

67.78

 

Diclofenac

53.52 (24.69)

37.60* (24.06)

28.19* (22.40)

21.12* (21.16)

12.86* (16.69)

75.97

   Pain during climbing up and down stairs

DJW

63.08 (20.87)

46.31* (26.56)

36.40* (25.67)

28.16* (24.03)

18.41* (21.50)

70.81

 

Diclofenac

62.69 (23.21)

43.90* (22.29)

32.61* (22.42)

24.59* (21.79)

15.83* (19.65)

74.75

   Night pain

DJW

50.15 (26.74)

33.44* (27.27)

23.56* (22.79)

15.68* (18.14)

9.27* (15.04)

81.52

 

Diclofenac

48.45 (28.18)

28.93* (22.82)

20.87* (19.56)

15.02* (17.87)

8.65* (14.68)

82.15

   Resting pain

DJW

38.48 (22.09)

27.25* (21.99)

19.96* (19.98)

12.64* (15.56)

7.42* (13.09)

80.72

 

Diclofenac

37.12 (26.08)

22.84* (20.62)

16.26* (18.19)

11.30* (16.40)

6.58* (13.96)

82.27

   Total painb

DJW

268.65 (88.87)

194.38* (105.06)

149.24* (103.19)

108.76* (92.54)

70.04* (83.94)

73.93

 

Diclofenac

266.55 (89.33)

177.34* (85.49)

132.91* (84.50)

96.21* (81.94)

58.23* (70.43)

78.15

   Pain during the most painful knee movement

DJW

82.25 (16.15)

63.31* (26.35)

49.77* (28.70)

37.69* (28.45)

26.81* (27.70)

67.40

 

Diclofenac

81.17 (16.56)

56.79* (24.87)

43.64* (27.30)

33.10* (27.17)

22.84* (25.85)

71.86

VAS that assessed stiffness (mm)

   Morning stiffness

DJW

53.53 (27.38)

36.61* (25.56)

28.04* (23.86)

19.66* (20.53)

12.34* (17.69)

76.95

 

Diclofenac

58.32 (26.40)

38.73* (23.87)

28.52* (21.93)

20.19* (20.23)

12.90* (17.34)

77.88

   Stiffness after rest

DJW

68.52 (22.76)

51.69* (24.93)

39.40* (25.31)

29.05* (24.60)

19.62* (23.06)

71.37

 

Diclofenac

70.45 (22.32)

49.71* (24.68)

39.54* (24.97)

28.23* (24.17)

18.90* (20.60)

73.17

   Total stiffnessc

DJW

122.05 (41.98)

88.30* (45.93)

67.44* (46.25)

48.71* (42.82)

31.96* (38.84)

73.81

 

Diclofenac

128.76 (42.34)

88.44* (43.84)

68.06* (43.03)

48.42* (41.97)

31.80* (36.07)

75.30

Lequesne's functional index (score)

DJW

14.20 (3.13)

11.60* (4.11)

11.05* (4.04)

9.93* (4.40)

8.92* (4.60)

37.18

 

Diclofenac

14.80 (2.61)

10.89* (3.38)

10.65* (3.55)

9.59* (3.52)

8.64* (3.83)

41.62

Time for climbing up 10 steps (s)

DJW

13.44 (4.85)

11.65* (4.75)

11.42* (4.67)

10.94* (4.73)

10.50* (4.38)

21.88

 

Diclofenac

13.32 (5.10)

11.26* (5.12)

11.14* (5.72)

10.61* (5.51)

10.18* (4.46)

23.57

  1. Data represent mean (SD). aCalculated by (meanweek0-meanweek4) × 100/meanweek0. bSummation of VAS that assessed walking pain, standing pain, pain during climbing up and down stairs, night pain and resting pain. cSummation of VAS that assessed morning stiffness and stiffness after rest. *p < 0.05 versus base-line value.
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