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Table 2 Percentage blood glucose reduction produced by C. roseus after oral administration in alloxan-induced diabetic rabbits.

From: The juice of fresh leaves of Catharanthus roseus Linn. reduces blood glucose in normal and alloxan diabetic rabbits

Group

(n = 5)

Dose

Initial Blood glucose (mg/dl)

Percent blood glucose reduction

   

4

6

8

10

12

16

18

20

24 (h)

Control

---

324.7

1.2 ± 0.3

0.7 ± 0.3

0.1 ± 0.3

-0.5 ± 0.4

-0.5 ± 0.2

0.2 ± 0.5

-0.6 ± 1.9

-0.7 ± 0.1

-0.2 ± 0.3

C. roseus

0.50 ml/kg

316.0

10.5 ± 1.9**

14.9 ± 0.8***

19.6 ± 0.5***

16.85 ± 0.8***

13.4 ± 4.9**

8.9 ± 1.9**

7.7 ± 2.4*

6.3 ± 1.3***

4.4 ± 1.6*

C. roseus

0.75 ml/kg

304.9

14.6 ± 4.5*

16.7 ± 2.5***

22.2 ± 3.8***

24.5 ± 7.4**

27.8 ± 6.5**

27.4 ± 3.5***

31.4 ± 5.6***

25.8 ± 5.1***

19.4 ± 6.4*

C. roseus

1.0 ml/kg

319.2

16.8 ± 5.8*

20.9 ± 5.5**

24.1 ± 2.9***

26.6 ± 4.9***

27.5 ± 9.2*

30.4 ± 6.9*

32.7 ± 6.0***

36.5 ± 4.8***

31.8 ± 8.5**

Glibenclamide

40 μg/kg

323.9

22.6 ± 3.6***

28.5 ± 5.5***

34.9 ± 4.6***

28.7 ± 6.5**

24.8 ± 5.7**

24.6 ± 4.1***

21.3 ± 5.6**

17.4 ± 9.8

14.5± 5.9*

  1. Values are mean percent blood glucose reduction (± S.E.M.) of five animals. Significant difference from control at corresponding intervals: *p < 0.05, **p < 0.01, ***p < 0.001