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Table 2 Percentage blood glucose reduction produced by C. roseus after oral administration in alloxan-induced diabetic rabbits.

From: The juice of fresh leaves of Catharanthus roseus Linn. reduces blood glucose in normal and alloxan diabetic rabbits

Group
(n = 5)
Dose Initial Blood glucose (mg/dl) Percent blood glucose reduction
    4 6 8 10 12 16 18 20 24 (h)
Control --- 324.7 1.2 ± 0.3 0.7 ± 0.3 0.1 ± 0.3 -0.5 ± 0.4 -0.5 ± 0.2 0.2 ± 0.5 -0.6 ± 1.9 -0.7 ± 0.1 -0.2 ± 0.3
C. roseus 0.50 ml/kg 316.0 10.5 ± 1.9** 14.9 ± 0.8*** 19.6 ± 0.5*** 16.85 ± 0.8*** 13.4 ± 4.9** 8.9 ± 1.9** 7.7 ± 2.4* 6.3 ± 1.3*** 4.4 ± 1.6*
C. roseus 0.75 ml/kg 304.9 14.6 ± 4.5* 16.7 ± 2.5*** 22.2 ± 3.8*** 24.5 ± 7.4** 27.8 ± 6.5** 27.4 ± 3.5*** 31.4 ± 5.6*** 25.8 ± 5.1*** 19.4 ± 6.4*
C. roseus 1.0 ml/kg 319.2 16.8 ± 5.8* 20.9 ± 5.5** 24.1 ± 2.9*** 26.6 ± 4.9*** 27.5 ± 9.2* 30.4 ± 6.9* 32.7 ± 6.0*** 36.5 ± 4.8*** 31.8 ± 8.5**
Glibenclamide 40 μg/kg 323.9 22.6 ± 3.6*** 28.5 ± 5.5*** 34.9 ± 4.6*** 28.7 ± 6.5** 24.8 ± 5.7** 24.6 ± 4.1*** 21.3 ± 5.6** 17.4 ± 9.8 14.5± 5.9*
  1. Values are mean percent blood glucose reduction (± S.E.M.) of five animals. Significant difference from control at corresponding intervals: *p < 0.05, **p < 0.01, ***p < 0.001