Group (n = 5) | Dose | Initial Blood glucose (mg/dl) | Percent blood glucose reduction | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
4 | 6 | 8 | 10 | 12 | 16 | 18 | 20 | 24 (h) | |||
Control | --- | 324.7 | 1.2 ± 0.3 | 0.7 ± 0.3 | 0.1 ± 0.3 | -0.5 ± 0.4 | -0.5 ± 0.2 | 0.2 ± 0.5 | -0.6 ± 1.9 | -0.7 ± 0.1 | -0.2 ± 0.3 |
C. roseus | 0.50 ml/kg | 316.0 | 10.5 ± 1.9** | 14.9 ± 0.8*** | 19.6 ± 0.5*** | 16.85 ± 0.8*** | 13.4 ± 4.9** | 8.9 ± 1.9** | 7.7 ± 2.4* | 6.3 ± 1.3*** | 4.4 ± 1.6* |
C. roseus | 0.75 ml/kg | 304.9 | 14.6 ± 4.5* | 16.7 ± 2.5*** | 22.2 ± 3.8*** | 24.5 ± 7.4** | 27.8 ± 6.5** | 27.4 ± 3.5*** | 31.4 ± 5.6*** | 25.8 ± 5.1*** | 19.4 ± 6.4* |
C. roseus | 1.0 ml/kg | 319.2 | 16.8 ± 5.8* | 20.9 ± 5.5** | 24.1 ± 2.9*** | 26.6 ± 4.9*** | 27.5 ± 9.2* | 30.4 ± 6.9* | 32.7 ± 6.0*** | 36.5 ± 4.8*** | 31.8 ± 8.5** |
Glibenclamide | 40 μg/kg | 323.9 | 22.6 ± 3.6*** | 28.5 ± 5.5*** | 34.9 ± 4.6*** | 28.7 ± 6.5** | 24.8 ± 5.7** | 24.6 ± 4.1*** | 21.3 ± 5.6** | 17.4 ± 9.8 | 14.5± 5.9* |