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Table 2 Showing frequency distribution of mitotic indices (Ml) in 5000 cells, chromosome aberration (CA) in 500 cells, micronuclei (MN) in polychromatic (PCE) and normochromatic (NCE) erythrocytes in 5000 cells and sperm head anomaly (SHA) in 5000 sperm in mice treated with p-Dimethylaminoazobenzene (DAB) + Phenobarbital (PB), DAB + PB + Chelidonium (Ch)-30 and DAB + PB + Chelidonium (Ch)-200 and their Phenobarbital treated and normal controls. Equal number of cells/sperms observed from each of 5 mice of a set.

From: Effect of a homeopathic drug, Chelidonium, in amelioration of p-DAB induced hepatocarcinogenesis in mice

   Mitotic Index Chromosome Aberration Micronucleated Erythrocytes Sperm Head Anomaly
Fixation intervals (days) Series % of Ml (% ± SE) % of Prot. % of Major CA % of Other CA Total CA (% ± SE) % of Prot. % of MN in PCE % of MN in NCE P/N Total MN (% ± SE) % of Prot. Total SHA (% ± SE) % of Prot.
  Normal 1.32 ± 0.08   1.4 1.4 2.80 ± 0.58   0.04 0.26 0.89 0.16 ± 0.05   0.44 ± 0.12  
  PB 2.10 ± 0.48   1.6 1.8 3.40 ± 0.98   0.14 0.28 0.74 0.16 ± 0.05   1.08 ± 0.24  
60 DAB + PB 8.70 ± 0.79   5.4 10.4 15.8 ± 2.11   0.53 0.88 0.84 0.72 ± 0.14   2.62 ± 0.28  
  DAB + PB + Ch-30 4.66 ± 0.34 4.04b 4.4 4.6 9.0 ± 0.78 6.8a 0.41 0.61 0.79 0.52 ± 0.09 0.20 1.66 ± 0.30 0.96a
  DAB + PB + Ch-200 3.36 ± 0.37 5.34c 4.6 8.2 12.8 ± 3.87 3.0 0.45 0.26 0.497 0.32 ± 0.08 0.42a 0.8 ± 0.11 1.82c
  Normal 1.32 ± 0.08   1.4 1.4 2.80 ± 0.58   0.04 0.26 0.89 0.16 ± 0.05   0.44 ± 0.12  
  PB 1.58 ± 0.14   2.2 3.0 5.20 ± 0.86   0.13 0.22 0.83 0.180.08   0.52 ± 0.09  
90 DAB + PB 6.40 ± 1.14   6.6 4.2 10.8 ± 1.20   1.17 0.27 0.80 0.67 ± 0.10   2.90 ± 0.27  
  DAB + PB + Ch-30 3.08 ± 0.29 3.3a 4.4 4.8 9.20 ± 1.86 1.6 0.24 0.55 1.33 0.37 ± 0.10 0.16 2.20 ± 0.26 0.70
  DAB + PB + Ch-200 2.90 ± 0.34 3.5a 4.6 5.6 10.2 ± 1.56 0.6 0.29 0.48 1.16 0.38 ± 0.11 0.16 1.66 ± 0.16 1.24b
  Normal 1.32 ± 0.08   1.4 1.4 2.80 ± 0.58   0.04 0.26 0.89 0.16 ± 0.05   0.44 ± 0.12  
  PB 2.12 ± 0.30   2.4 4.2 6.60 ± 0.93   0.21 0.11 0.91 0.16 ± 0.08 1.12 ± 0.12
120 DAB + PB 8.20 ± 0.26   8.6 13.0 22.4 ± 0.25   0.63 0.54 0.80 0.58 ± 0.15   1.58 ± 0.31  
  DAB + PB + Ch-30 8.72 ± 0.65 -0.52 7.8 7 14.8 ± 2.18 7.6b 0.49 0.27 0.34 0.32 ± 0.08 0.32 0.40 ± 0.12 1.18b
  DAB + PB + Ch-200 6.44 ± 0.35 1.8b 3.8 4.2 8.0 ± 0.32 14.4c 0.12 0.19 2.18 0.14 ± 0.06 0.43a 0.38 ± 0.07 1.20b
  1. Major Types of CA include: Break; Centric fusion; Translocation; Fragment; Pulverisation; Ring; Terminal association; Polyploidy.;Aneuploidy. Other types of CA include: Erosion, Constriction, Precocious centromeric separation, Centromericstrecthing, Stickiness, C-mitotic effect. SE= standard error, a= p < 0.05, b= p < 0.01, c= p < 0.001. Prot.= Protection given by the drug
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