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Table 2 Showing frequency distribution of mitotic indices (Ml) in 5000 cells, chromosome aberration (CA) in 500 cells, micronuclei (MN) in polychromatic (PCE) and normochromatic (NCE) erythrocytes in 5000 cells and sperm head anomaly (SHA) in 5000 sperm in mice treated with p-Dimethylaminoazobenzene (DAB) + Phenobarbital (PB), DAB + PB + Chelidonium (Ch)-30 and DAB + PB + Chelidonium (Ch)-200 and their Phenobarbital treated and normal controls. Equal number of cells/sperms observed from each of 5 mice of a set.

From: Effect of a homeopathic drug, Chelidonium, in amelioration of p-DAB induced hepatocarcinogenesis in mice

  

Mitotic Index

Chromosome Aberration

Micronucleated Erythrocytes

Sperm Head Anomaly

Fixation intervals (days)

Series

% of Ml (% ± SE)

% of Prot.

% of Major CA

% of Other CA

Total CA (% ± SE)

% of Prot.

% of MN in PCE

% of MN in NCE

P/N

Total MN (% ± SE)

% of Prot.

Total SHA (% ± SE)

% of Prot.

 

Normal

1.32 ± 0.08

 

1.4

1.4

2.80 ± 0.58

 

0.04

0.26

0.89

0.16 ± 0.05

 

0.44 ± 0.12

 
 

PB

2.10 ± 0.48

 

1.6

1.8

3.40 ± 0.98

 

0.14

0.28

0.74

0.16 ± 0.05

 

1.08 ± 0.24

 

60

DAB + PB

8.70 ± 0.79

 

5.4

10.4

15.8 ± 2.11

 

0.53

0.88

0.84

0.72 ± 0.14

 

2.62 ± 0.28

 
 

DAB + PB + Ch-30

4.66 ± 0.34

4.04b

4.4

4.6

9.0 ± 0.78

6.8a

0.41

0.61

0.79

0.52 ± 0.09

0.20

1.66 ± 0.30

0.96a

 

DAB + PB + Ch-200

3.36 ± 0.37

5.34c

4.6

8.2

12.8 ± 3.87

3.0

0.45

0.26

0.497

0.32 ± 0.08

0.42a

0.8 ± 0.11

1.82c

 

Normal

1.32 ± 0.08

 

1.4

1.4

2.80 ± 0.58

 

0.04

0.26

0.89

0.16 ± 0.05

 

0.44 ± 0.12

 
 

PB

1.58 ± 0.14

 

2.2

3.0

5.20 ± 0.86

 

0.13

0.22

0.83

0.180.08

 

0.52 ± 0.09

 

90

DAB + PB

6.40 ± 1.14

 

6.6

4.2

10.8 ± 1.20

 

1.17

0.27

0.80

0.67 ± 0.10

 

2.90 ± 0.27

 
 

DAB + PB + Ch-30

3.08 ± 0.29

3.3a

4.4

4.8

9.20 ± 1.86

1.6

0.24

0.55

1.33

0.37 ± 0.10

0.16

2.20 ± 0.26

0.70

 

DAB + PB + Ch-200

2.90 ± 0.34

3.5a

4.6

5.6

10.2 ± 1.56

0.6

0.29

0.48

1.16

0.38 ± 0.11

0.16

1.66 ± 0.16

1.24b

 

Normal

1.32 ± 0.08

 

1.4

1.4

2.80 ± 0.58

 

0.04

0.26

0.89

0.16 ± 0.05

 

0.44 ± 0.12

 
 

PB

2.12 ± 0.30

 

2.4

4.2

6.60 ± 0.93

 

0.21

0.11

0.91

0.16 ± 0.08

1.12 ± 0.12

120

DAB + PB

8.20 ± 0.26

 

8.6

13.0

22.4 ± 0.25

 

0.63

0.54

0.80

0.58 ± 0.15

 

1.58 ± 0.31

 
 

DAB + PB + Ch-30

8.72 ± 0.65

-0.52

7.8

7

14.8 ± 2.18

7.6b

0.49

0.27

0.34

0.32 ± 0.08

0.32

0.40 ± 0.12

1.18b

 

DAB + PB + Ch-200

6.44 ± 0.35

1.8b

3.8

4.2

8.0 ± 0.32

14.4c

0.12

0.19

2.18

0.14 ± 0.06

0.43a

0.38 ± 0.07

1.20b

  1. Major Types of CA include: Break; Centric fusion; Translocation; Fragment; Pulverisation; Ring; Terminal association; Polyploidy.;Aneuploidy. Other types of CA include: Erosion, Constriction, Precocious centromeric separation, Centromericstrecthing, Stickiness, C-mitotic effect. SE= standard error, a= p < 0.05, b= p < 0.01, c= p < 0.001. Prot.= Protection given by the drug
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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