Table 1 Showing some salient changes in liver histology of p-DAB+PB treated mice (showing tumors) as compared to untreated controls
p-DAB + PB treated series showing tumors | Normal control series without tumor |
|---|---|
In majority of cells, more than one nucleus per cell present, some nuclei very large | Generally one nucleus per cell present |
Vacuolated cytoplasm and loss of distinct cell outline in most cells, | Cytoplasm not vacuolated |
The number of hepatocytes, bile and duct cells increased | Number of hepatocytes bile and duct cells relatively few |
The spaces between adjacent cells not well-defined | Cell outline distinct and spaces between adjacent cells well-defined |