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Figure 5 | BMC Complementary and Alternative Medicine

Figure 5

From: Muscadine grape skin extract reverts snail-mediated epithelial mesenchymal transition via superoxide species in human prostate cancer cells

Figure 5

MSKE may exert its inhibitory effect on EMT and/or superoxide via antagonizing the JAK/STAT pathway in prostate cancer cells (A) STAT-3 and p-STAT-3 levels in ARCaP Neo and ARCaP-Snail med and ARCaP-Snail high (B) ARCaP-Snail med and (C) ARCaP Snail high cells were treated with 5 μg/ml MSKE and 20 μg/ml for 3 days followed by analysis of STAT-3 and p-STAT-3 by western blot. Compared to untreated or DMSO control treated, 20 μg/ml showed a decrease in STAT-3 and p-STAT-3 as compared to 5 μg/ml MSKE or control. Untreated cells were utilized as controls. Actin was used as a loading control.

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