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Figure 4 | BMC Complementary and Alternative Medicine

Figure 4

From: Muscadine grape skin extract reverts snail-mediated epithelial mesenchymal transition via superoxide species in human prostate cancer cells

Figure 4

MSKE and SOD can revert Snail-mediated EMT in ARCaP cells. (A) ARCaP-Snail high cells were treated with 5 or 20 μg/ml MSKE for 3 days and Snail, E-cadherin and vimentin EMT markers analyzed by Western blot analyses. 5 μg/ml reverted EMT more efficiently than 20 μg/ml as observed by decreased vimentin and increased E-cadherin, as compared to untreated or EtOH-treated Snail high cells. (B) ARCaP-Snail med cells were treated with 5 μg/ml MSKE or 500 U/ml SOD for 3 days followed by analysis of Snail, E-cadherin and vimentin by Western blot. Both MSKE and SOD reverted EMT as shown by increased E-cadherin and decreased vimentin. Untreated or EtOH treated cells were utilized as controls. Actin was used as a loading control.

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