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Figure 2 | BMC Complementary and Alternative Medicine

Figure 2

From: Abundant expression and functional participation of TRPV1 at Zusanli acupoint (ST36) in mice: mechanosensitive TRPV1 as an “acupuncture-responding channel”

Figure 2

Manual acupuncture (MA) at ST36 yielded an analgesic effect in mouse CFA inflammatory pain model. On day 3 (D3) after CFA injection, MA, sham treatment (Sham), or needling without twisting (Needle) were administered at ST36 or sham point. Hargraves’ thermal test was performed before CFA injection (D0), on D3 preintervention (D3 pre), on D3 postintervention (D3 post, 60 min after intervention), and on D4 (24 h after intervention). (A) MA at ST36 yielded an analgesic effect in within-group tests on D3 post (P < 0.05) and on D4 (P < 0.05). (B) Between-group tests showed that MA yielded significant differences compared with CFA (P < 0.05), Sham (P < 0.05), and Needle (P < 0.05) groups on D3 post. (C) No significant differences were observed on D4 in between-group tests (*P < 0.05, Mann–Whitney rank sum test, n = 9–14). Data are means ± S.E.M.

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