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Table 3 Eligibility criteria for the PATH-D study

From: Mindfulness-based cognitive therapy (MBCT) versus the health-enhancement program (HEP) for adults with treatment-resistant depression: a randomized control trial study protocol

Inclusion criteria Exclusion criteria
- Age 18 or older - Clinically significant suicide risk
- Current major depression (DSM-IV-TR criteria) - History of schizophrenia or psychotic symptoms
- HAM-D total score ≥ 14 - Bipolar disorder
- Total ATHF Intensity score ≥5 for 2 or more antidepressant medications - Obsessive compulsive disorder
- Evidence of two failed adequate antidepressant trials in the current depressive episode - Alcohol or substance abuse or dependence within the past 3 months
- Current use of antidepressants - Insufficient ability to understand or read English
  - MMSE total score < 25
  - Severe medical illness determined by the CIRS
  - History of meditation practice or currently meditation more than 1 time per week
  - Currently practicing yoga more than 2 times per week
  1. Note. HAM-D = Hamilton Depression Rating Scale; ATHF = Antidepressant Treatment History Form; MMSE = Mini Mental Status Exam; CIRS = Cumulative Illness Rating Scale.
  2. *Axis I anxiety disorders are not excluded as they are highly co-morbid with depression. This study is designed to approximate a real world, clinical setting, and anxiety disorders were not excluded in the original MBCT studies nor in the STAR*D trials.