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Table 3 Human BACE-1 inhibitory in vitro activity of four curcuminoids, two phytochemicals and BACE-1 inhibitor IV

From: Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer’s disease Drosophila models

Compound IC50, μM (95% CL) Slope ± SE
Curcumin 340 (296–391) 0.7 ± 0.03
Demethoxycurcumin 217 (197–240) 1.0 ± 0.05
Bisdemethoxycurcumin 17 (14–20) 1.9 ± 0.21
Tetrahydrocurcumin > 2000  
(−)-Epigallocatechin gallate 82.01(72.59–92.66) 0.9 ± 0.04
BACE-1 inhibitor IV 0.085 (0.075–0.095) 1.2 ± 0.07