Effect of curcumin, bisdemethoxycurcumin, and β-secretase Inhibitor IV supplementation on longevity of elav-Gal4/+, elav < BACE-1, and elav < APP/BACE-1 flies. There was no significant difference in the longevity among three different genotype flies (A). Compound supplementation did not affect longevity of flies elav-Gal4/+ (B), elav < BACE-1 (C), and elav < APP/BACE-1 (D). Median life time of three genotype flies cultured on standard medium (n = 200 flies per group. ***: p < 0.001, **: p < 0.01, *: p < 0.05) (E). Median life time of three genotype flies fed on curcuminoids and BACE-1 Inhibitor IV supplementation media (n = 200 flies per group. **: p < 0.01, *: p < 0.05) (F). Each bar represents standard error.