Figure 5

Rough eye phenotype associated with GMR < APP/BACE-1 Drosophila eye development observed by light microscope and scanning electron microscope. Light micrographs of GMR < GAL4 flies (A1-A3), GMR < APP/BACE-1 cultured on 0.1% DMSO (B1-B3), 1 mM curcumin (C1-C3), 1 mM bisdemethoxycurcumin (D1-D3), and 200 nM β-secretase Inhibitor IV (E1-E3). Scanning electron micrographs of day 36 GMR < GAL4 flies (A4) and GMR < APP/BACE-1 cultured on different media (B4-E4). Stars indicate ommatidia atrophia.