Figure 3

Human APP and BACE-1 genes induced eye degeneration of transgenic fly under GMR-Gal4 driver strain. Control GMR-Gal4/+ flies showed normal and well-organized compounds eye (A), this well-organized structure were stained by Cason’s trichome staining (B) and Congo red staining (C and D). Transgenic flies GMR < APP/BACE-1 presented rough and irregular compound eye (E), damages of retina were detected by Cason’s trichome staining (F) and amyloid depositions were observed in flies’ compound eyes by Congo red staining marked by arrows (G and H). Scale bar, 50 μm.